649748-91-4Relevant academic research and scientific papers
Synthesis of indoloquinolones, triazoloindoloquinolines and its derivatives
Mulwad,Lohar
, p. 1937 - 1942 (2007/10/03)
1H,2H-2-Oxo-4-hydrazinoquinolines 1a-e on treatment with cyclohexanone give corresponding 1H,2H-2-oxo-4-quinolinylcyclohexanonehydrazones 2a-e. Thermal Fischer indolization of 2a-e yield 5,6-dihydro-11H-6-oxo-indolo[3,2-c]quinoline 3a-e. Chlorination of 3a-e affords the corresponding chloro compounds 11H-6-chloroindolo [3,2-c]quinolines 4a-e, which on treatment with hydrazine hydrate give 11H-6-indolo [3,2-c]quinolinylhydrazines 5a-e. This hydrazone is used as a building block to synthesize corresponding 3-chloro-1′-(11H-indolo[3,2-c]quinolin-6′ yl-amino)-4-(4′-nitrophenyl) azetidin-2-ones 7a-e and 1-phenyl-8H-indolo[3,2-c]quinolin[3′,4′: 1,2] triazoles 8a-e. 1a-e on treatment with p-nitrobenzaldehyde give 4-quinolinylhydrazono-1-4′ -nitrophenyl methanes 9a-e, which on further treatment with chloroacetyl chloride in triethyl amine afford 3-chloro-1′-(4-quinolin-4′ yl-amino)-4-(4′-nitrophenyl)azetidin-2-ones 10a-e. Some of these compounds have been screened for their biological activity.
