64989-74-8

Basic information

• Product Name: ETHYL 2-CHLORO-2-[2-(2-FLUOROPHENYL)HYDRAZONO]-ACETATE
• Synonyms: ETHYL 2-CHLORO-2-[2-(2-FLUOROPHENYL)HYDRAZONO]-ACETATE;Ethyl 2-chloro-2-[2-(2-fluorophenyl)hydrazono]-;Ethyl chloro[(2-fluorophenyl)hydrazono]acetate;ethyl (2Z)-2-chloro-2-[2-(2-fluorophenyl)hydrazin-1-ylidene]acetate
• CAS NO: 64989-74-8
• Molecular Formula: C₁₀H₁₀ClFN₂O₂
• Molecular Weight: 244.65
• Mol File: 64989-74-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 301.8°C at 760 mmHg
• Flash Point: 136.3°C
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 0.00103mmHg at 25°C
• Refractive Index: 1.531
• CAS DataBase Reference: ETHYL 2-CHLORO-2-[2-(2-FLUOROPHENYL)HYDRAZONO]-ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-CHLORO-2-[2-(2-FLUOROPHENYL)HYDRAZONO]-ACETATE(64989-74-8)
• EPA Substance Registry System: ETHYL 2-CHLORO-2-[2-(2-FLUOROPHENYL)HYDRAZONO]-ACETATE(64989-74-8)

Safety Data

• Hazardous Substances Data: 64989-74-8(Hazardous Substances Data)

Usage

General Description

Ethyl 2-chloro-2-[2-(2-fluorophenyl)hydrazono]-acetate is a chemical compound with the molecular formula C10H10ClFNO2. It is a yellow solid with a molecular weight of 225.64 g/mol. ETHYL 2-CHLORO-2-[2-(2-FLUOROPHENYL)HYDRAZONO]-ACETATE is used in organic synthesis and pharmaceutical research as a reagent and intermediate. It is important to handle this compound with care and precaution, as it is considered harmful if swallowed, inhaled, or in contact with skin. Additionally, it may cause irritation to the respiratory system and skin.

InChI:InChI=1/C10H10ClFN2O2/c1-2-16-10(15)9(11)14-13-8-6-4-3-5-7(8)12/h3-6,13H,2H2,1H3/b14-9+

Upstream product

• 348-54-9 2-Fluoroaniline 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 1314013-30-3 C₁₇H₁₃FN₂O₂ 
• 1284281-54-4 N-(4-cyanotetrahydro-2H-pyran-4-yl)-1-(2-fluorophenyl)-5-(4-methoxyphenyl)-4-methyl-1H-pyrazole-3-carboxamide 
• 1284281-43-1 N-(4-cyanotetrahydro-2H-pyran-4-yl)-1-(2-fluorophenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxamide 
• 1284281-24-8 ethyl 1-(2-fluorophenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylate 

Relevant articles and documents

Novel 4-phenoxypyridine derivatives bearing imidazole-4-carboxamide and 1,2,4-triazole-3-carboxamide moieties: Design, synthesis and biological evaluation as potent antitumor agents

Two series of novel 4-phenoxypyridine derivatives containing imidazole-4-carboxamide and 4-methyl-5-oxo-4,5-dihydro-1,2,4-triazole-3-carboxamide moieties were synthesized and evaluated for their in vitro inhibitory activities against c-Met kinase and anti

Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors

A new series of 7-aminopyrazolo[4,3-d]pyrimidine derivatives (1-31) were synthesized to evaluate some structural modifications at the 2- and 5-positions aimed at shifting affinity towards the human (h) A2A adenosine receptor (AR) or both hA2A and hA1 ARs. The most active compounds were those featured by a 2-furyl or 5-methylfuran-2-yl moiety at position 5, combined with a benzyl or a substituted-benzyl group at position 2. Several of these derivatives (22-31) displayed nanomolar affinity for the hA2A AR (Ki = 3.62-57 nM) and slightly lower for the hA1 ARs, thus showing different degrees (3-22 fold) of hA2A versus hA1 selectivity. In particular, the 2-(2-methoxybenzyl)-5-(5-methylfuran-2-yl) derivative 25 possessed the highest hA2A and hA1 AR affinities (Ki = 3.62 nM and 18 nM, respectively) and behaved as potent antagonist at both these receptors (cAMP assays). Its 2-(2-hydroxybenzyl) analog 26 also showed a high affinity for the hA2A AR (Ki = 5.26 nM) and was 22-fold selective versus the hA1 subtype. Molecular docking investigations performed at the hA2A AR crystal structure and at a homology model of the hA1 AR allowed us to represent the hypothetical binding mode of our derivatives and to rationalize the observed SARs.