650-89-5

Usage

Uses

Used in Pharmaceutical Industry:
4-(TRIFLUOROMETHYLSULFONYL)BENZALDEHYDE is used as a chemical intermediate for the synthesis of R-102557 and related dioxane-triazole derivatives, which have demonstrated excellent in vivo activities against various fungal species, including Candida, Aspergillus, and Cryptococcus. This makes it a valuable compound in the development of new antifungal medications.
Used in Chemical Research:
As a white crystalline solid with unique chemical properties, 4-(TRIFLUOROMETHYLSULFONYL)BENZALDEHYDE can be utilized in various chemical research applications, particularly in the study of organic synthesis and the development of novel compounds with potential applications in various fields, such as pharmaceuticals, materials science, and agrochemicals.

InChI:InChI=1/C8H5F3O3S/c9-8(10,11)14-15(13)7-3-1-6(5-12)2-4-7/h1-5H

Upstream product

• 219872-98-7 4-(trifluoromethylsulfonyl)benzyl alcohol 
• 56456-52-1 (4-((trifluoromethyl)thio)phenyl)methanol 
• 312-21-0 4-[(trifluoromethyl)sulfonyl] benzonitrile 

Downstream Products

• 934490-03-6 (E)-3-(4-Trifluoromethanesulfonyl-phenyl)-acrylic acid ethyl ester 
• 1027970-09-7 (2E,4E)-5-(4-Trifluoromethanesulfonyl-phenyl)-penta-2,4-dienoic acid ethyl ester 
• 219872-97-6 (E)-3-(4-Trifluoromethanesulfonyl-phenyl)-propenal 
• 1002129-13-6 (E)-3-(4-Trifluoromethanesulfonyl-phenyl)-prop-2-en-1-ol 
• 1026078-16-9 (2E,4E)-5-(4-Trifluoromethanesulfonyl-phenyl)-penta-2,4-dienal 
• 1027028-44-9 (2E,4E)-5-(4-Trifluoromethanesulfonyl-phenyl)-penta-2,4-dien-1-ol 
• 140682-45-7 2,2-dimethyl-4-phenyl-6-(4-trifluoromethylsulfonylphenyl)-1,3-diazabicyclo<3.1.0>hex-3-ene 
• 140682-42-4 5-phenyl-7-(4-trifluoromethylsulfonylphenyl)-1,4-diazabicyclo<4.1.0>hept-4-ene 
• 140682-47-9 1-(trifluoromethylsulfonylphenyl)-2-phenyl-1,1a-dihydroaziridino<1,2-a>quinoxaline 
• 140682-34-4 1-phenyl-3-(4-trifluoromethylsulfonylphenyl)-2,3-dibromo-1-propanone 
• 118089-89-7 1-(bromomethyl)-4-(trifluoromethylsulfonyl)benzene 
• 219872-98-7 4-(trifluoromethylsulfonyl)benzyl alcohol 

Relevant academic research and scientific papers

HALOALLYLAMINE PYRAZOLE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF

The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as i

Synthesis and antifungal activities of R-102557 and related dioxane- triazole derivatives

Novel triazole compounds with a dioxane ring were synthesized. Condensation of the diol precursor 10 with various aromatic aldehydes 11 - 13 under acidic conditions afforded a series of dioxane-triazole compounds 14 - 16. The antifungal activities of the compounds 14 - 16 were evaluated in vivo in mice infection models against Candida and Aspergillus species. High activities were seen for the derivatives with one or two double bond(s) and an aromatic ring substituted with an electron-withdrawing group in the side chain. Among the derivatives, R-102557 (16R: Ar=4-(2,2,3,3- tetrafluoropropoxy)phenyl) showed excellent in vivo activities against Candida, Aspergillus and Cryptococcus species. It also showed high tolerance in a preliminary toxicity study in rats.