65003-28-3

Basic information

• Product Name: Methanone, (3,4-dinitrophenyl)-4-Morpholinyl-
• Synonyms: Methanone, (3,4-dinitrophenyl)-4-Morpholinyl-;Morpholine, 4-(3,4-dinitrobenzoyl)-;4-morpholinocarbonyl-1,2-dinitrobenzene;(3,4-Dinitrophenyl)(morpholino)methanone
• CAS NO: 65003-28-3
• Molecular Formula: C₁₁H₁₁N₃O₆
• Molecular Weight: 281.22154
• Mol File: 65003-28-3.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methanone, (3,4-dinitrophenyl)-4-Morpholinyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (3,4-dinitrophenyl)-4-Morpholinyl-(65003-28-3)
• EPA Substance Registry System: Methanone, (3,4-dinitrophenyl)-4-Morpholinyl-(65003-28-3)

Safety Data

• Hazardous Substances Data: 65003-28-3(Hazardous Substances Data)

Usage

General Description

Methanone, (3,4-dinitrophenyl)-4-Morpholinyl- is a chemical compound that consists of a methanone group attached to a 4-morpholinyl moiety and a 3,4-dinitrophenyl group. It is commonly used as a reagent in organic synthesis and as a tool in chemical research. The compound's unique structure and properties make it useful in a variety of applications, including pharmaceuticals, agrochemicals, and materials science. Its ability to undergo various chemical reactions and form stable intermediates makes it a valuable component in the development of new compounds and materials. Additionally, it has potential uses in the field of medicinal chemistry and drug discovery. Overall, Methanone, (3,4-dinitrophenyl)-4-Morpholinyl- is a versatile and important chemical in the natural and applied sciences.

Upstream product

• 528-45-0 3,4-dinitrobenzoic acid 
• 110-91-8 morpholine 
• 24376-18-9 3,4-dinitrobenzoyl chloride 

Downstream Products

• 825619-02-1 4-morpholin-4-ylmethylbenzene-1,2-diamine 
• 825619-29-2 4-((2-(4-nitro-1H-pyrazol-3-yl)-1H-benzo[d]imidazole-5-yl)methyl)morpholine 
• 1254229-30-5 N-{4-[4-chloro-6-({3-[5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl]-1H-pyrazol-4-yl}amino)pyrimidin-2-ylthio]phenyl}cyclopropanecarboxamide 
• 65003-29-4 (3,4-diaminophenyl)(morpholin-4-yl)methanone 
• 825619-03-2 4-(3,4-dinitrobenzyl)-morpholine 

Relevant articles and documents

Pyrazole spleen tyrosine kinase inhibitor as well as preparation method and application thereof

The invention discloses a pyrazole spleen tyrosine kinase inhibitor, a preparation method thereof, a pharmaceutical composition containing the same, and application of the pyrazole spleen tyrosine kinase inhibitor and the pharmaceutical composition in the preparation of drugs for treating Syk-mediated diseases including cancers, inflammatory diseases and the like.

As Aurora kinase inhibitor derivatives

The present invention relates to a substituted pyrazole derivative used for inhibiting Aurora kinase and represented by formula (I) or formula (Ia), or stereo isomers, geometric isomers, tautomers, nitrogen oxides, hydrates, solvates, metabolites, esters, pharmaceutically acceptable salts or prodrugs thereof, a medicinal composition containing the above compounds as active ingredients, and a use of the compounds and the medicinal composition in preparation of medicines for protecting, processing, treating or mitigating proliferative diseases of patients.

HPK1 INHIBITORS AND METHODS OF USING SAME

Thienopyridinone compounds of Formula (I) and pharmaceutically acceptable salts thereof are described. In these compounds, one of X1; X2, and X3 is S and the other two are each independently CR, wherein R and all other variables are as defined herein. The compounds are shown to inhibit HPK1 kinase activity and to have in vivo antitumor activity. The compounds can be effectively combined with pharmaceutically acceptable carriers and also with other immunomodulatory approaches, such as checkpoint inhibition or inhibitors of tryptophan oxidation. Formula (I).