65025-95-8Relevant articles and documents
Discovery of novel seven-membered prostacyclin analogues as potent and selective prostaglandin FP and EP3 Dual Agonists
Sugimoto, Isamu,Kambe, Tohru,Okino, Tomotaka,Obitsu, Tetsuo,Ohta, Nobukazu,Nishiyama, Taihei,Kinoshita, Akihiro,Fujimoto, Taku,Egashira, Hiromu,Yamane, Shinsaku,Shuto, Satoshi,Tani, Kousuke,Maruyama, Toru
supporting information, p. 107 - 112 (2017/12/12)
A novel series of prostaglandin analogues with a seven-membered ring scaffold was designed, synthesized, and evaluated for the functional activation of prostaglandin receptors to identify potent and subtype-selective FP and EP3 dual agonists. Starting fro
A process for the preparation of intermediates useful in the ruby's forefront, preparation method thereof and through its preparation ruby's forefront method
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Paragraph 0062-0064, (2017/08/03)
The invention relates to an intermediate for preparing lubiprostone, a preparation method of the intermediate and a method for preparing the lubiprostone through the intermediate, in particular to a compound as shown in a formula V for preparing the lubiprostone (as shown in a formula I), a preparation method of the compound and a method for preparing the lubiprostone through the compound. The method comprises the following steps: performing reduction treatment on the compound as shown in the formula V, performing selective deprotection and hydroxyl oxidation to obtain a compound as shown in a formula II, and performing hydroxyl deprotection on the compound as shown in the formula II to prepare the lubiprostone as shown in the formula I. The method is easy and convenient to operate, high in synthetic yield and suitable for large-scale production.
BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES
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Paragraph 0173-0175, (2013/12/03)
Provided is a compound which has strong intraocular pressure lowering action and has no side effect on eyes such as ocular stimulating property, humor protein rise etc. Since a compound represented by the formula (I): (wherein definition of each group is