65029-36-9

Usage

Uses

Used in Pharmaceutical Industry:
3H-1,2,4-Triazole-3-thione, 2,4-dihydro-5-(hydroxymethyl)-4-methyl(9CI) is used as a pharmaceutical agent for its antiviral, antimicrobial, and antifungal properties. Its diverse biological activities make it a potential candidate for the development of new drugs to combat various infections and diseases.
Used in Agrochemical Industry:
In the agrochemical field, 3H-1,2,4-Triazole-3-thione, 2,4-dihydro-5-(hydroxymethyl)-4-methyl(9CI) is utilized as a bioactive compound with potential applications in crop protection and enhancement of plant health. Its antimicrobial and antifungal properties can be harnessed to create new pesticides or fungicides to protect crops from diseases and pests, thereby increasing agricultural productivity.

Upstream product

• 623-50-7 ethyl 2-hydroxyacetate 
• 556-61-6 methyl thioisocyanate 
• 96-35-5 glycolic acid methyl ester 
• 6610-29-3 4-methylthiosemicarbazide 

Downstream Products

• 59660-30-9 (4-methyl-4H-1,2,4-triazol-3-yl)methanol 
• 1307845-24-4 C₁₁H₁₂ClN₃OS 

Relevant academic research and scientific papers

Discovery of non-glucoside SGLT2 inhibitors

A series of benzothiazinone and benzooxazinone derivatives were discovered as SGLT2 inhibitors. The optimization led to the discovery of compounds 31 and 32, which exhibited similar potency and better SGLT1 selectivity compared to dapagliflozin. These compounds may provide novel promising scaffolds, which are different from phlorizin-based SGLT2 inhibitors.

Non-nucleoside reverse transcriptase inhibitors

Compounds of formula I, wherein R1, R2, R3, R4, R5, X, Y, and Ar are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.

Orally active CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological activities of 1-benzazepine derivatives containing a sulfoxide moiety

In order to develop orally active CCR5 antagonists, 1-propyl- or 1-isobutyl-1-benzazepine derivatives containing a sulfoxide moiety have been designed, synthesized, and evaluated for their biological activities. Sulfoxide compounds containing a 2-pyridyl

7-[2-(2-Imino-4-thiazolin-4-yl)-2-(syn)-hydroxy-iminoacetamido]-cephalosporins

Disclosed are 2-(syn)-hydroxyimino-acetamide derivatives of the formula: STR1 wherein Y is hydrogen, hydroxyl, an acyloxy, carbamoyloxy, a quaternary ammonium or a nitrogen-containing heterocyclic ring-substituted thio group; or pharmaceutically acceptable salts or esters thereof are useful as antibacterial agents. Also disclosed are processes for producing them.