6504-13-8

Usage

Uses

Used in Pharmaceutical Industry:
4-(1H-BENZOIMIDAZOL-2-YL)-PHENOL is used as a building block for the synthesis of various drugs and bioactive molecules due to its unique chemical structure and potential pharmacological properties.
Used in Anti-inflammatory Applications:
HBBIP is used as an anti-inflammatory agent for its potential to inhibit enzymes involved in inflammation, providing a basis for the development of treatments targeting inflammatory conditions.
Used in Antioxidant Applications:
4-(1H-BENZOIMIDAZOL-2-YL)-PHENOL is used as an antioxidant agent for its potential to combat oxidative stress, which can contribute to the development of various diseases and conditions.
Used in Neurodegenerative Disease Treatment:
HBBIP is used in research for the treatment of neurodegenerative diseases, given its potential to target mechanisms involved in these conditions, offering a new avenue for therapeutic intervention.
Used in Cancer Treatment:
4-(1H-BENZOIMIDAZOL-2-YL)-PHENOL is used in cancer research for its potential role in inhibiting cancer-related processes, making it a candidate for the development of novel cancer therapies.

InChI:InChI=1/C13H10N2O/c16-10-7-5-9(6-8-10)13-14-11-3-1-2-4-12(11)15-13/h1-8,16H,(H,14,15)

Upstream product

• 85573-09-7 4-Hydroxy-benzaldehyd-(2-amino-pheylimin) 
• 69116-33-2 1,2-bis-(4-propoxy-benzoylamino)-benzene 
• 767-00-0 4-cyanophenol 
• 615-28-1 o-phenylenediamine dihydrochloride 
• 123-08-0 4-hydroxy-benzaldehyde 
• 95-54-5 1,2-diamino-benzene 
• 3179-08-6 4-(2-nitrovinyl)phenol 
• 107496-03-7 Carbamic acid 4-((E)-2-nitro-vinyl)-phenyl ester 
• 40782-58-9 p-propoxybenzoyl chloride 
• 51-17-2 benzoimidazole 
• 106-41-2 4-bromo-phenol 
• 85573-09-7 N-(4-hydroxybenzylidene)benzene-1,2-diamine 
• 99-93-4 4-Hydroxyacetophenone 
• 1635-61-6 5-chloro-2-nitroaniline 

Downstream Products

• 80493-55-6 ethyl-p-(2-benzimidazolyl) phenoxyacetate 
• 774221-47-5 (2S)-N-{3-(4-(1H-benzo[d]imidazolo-2-yl)phenoxy) propoxy-5-methoxy-2-aminobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 774221-48-6 (2S)-N-{3-(4-(1H-benzo[d]imidazolo-2-yl)phenoxy)butoxy-5-methoxy-2-aminobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 774221-49-7 (2S)-N-{5-(4-(1H-benzo[d]imidazolo-2-yl)phenoxy)pentyloxy-5-methoxy-2-aminobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 2620-82-8 1-methyl-2-(4-methoxyphenyl)-1H-benzimidazole 
• 1159707-24-0 C₁₆H₁₅ClN₂O 
• 1148018-30-7 C₁₉H₁₃N₃O₂ 
• 1159844-75-3 2-(4-(3-chloropropoxy)phenyl)-1-(3-chloropropyl)-1H-benzimidazole 
• 1138348-98-7 C₁₆H₁₂N₂O₂ 
• 47160-86-1 2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine 
• 17926-03-3 2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine 
• 1449214-96-3 N-{2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]ethyl}-N-isopropylpropan-2-amine 
• 1449214-97-4 2-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-1H-benzo[d]imidazole 
• 1379113-11-7 2-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1H-benzo[d]imidazole 

Relevant academic research and scientific papers

Systemic study on fluorescent switching systems composed of naphthopyran and benzimidazole in solution and film forms

The fluorescent photo-switching systems were prepared based on fluorescent benzimidazole and photochromic naphthopyran. Naphthopyran in this systems displayed excellent photochromic performance in tetrahydrofuran solutions and in PMMA films. The fluoresce

Inhibitory effects of benzimidazole containing new phenolic Mannich bases on human carbonic anhydrase isoforms hCA I and II

New phenolic mono and bis Mannich bases incorporating benzimidazole, such as 2-(aminomethyl)-4-(1H-benzimidazol-2-yl)phenol and 2,6-bis(aminomethyl)-4-(1H-benzimidazol-2-yl)phenol were synthesized starting from 4-(1H-benzimidazol-2-yl)phenol. Amines used

Stability constants of Ni(II)- and Cu(II)-N-heterocycle complexes according to spectrophotometric data

The interaction of Ni(II) and Cu(II) with ethyl 4-(4-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine- 5-carboxylate [Ligand 1], 4-(1H-benzimidazol-2-yl)phenol [Ligand 2], and 2-(3-phenylamino- 4,5-dihydro-1,2-oxazol-5-yl)phenol [Ligand 3] have been studied by spectrophotometric technique at 0.01 M ionic strength and 28°C in 70% dioxane - water mixture. The data obtained were used to estimate the stability constant of these ligands. Spectrophotometric investigation of Ni(II) and Cu(II) complexes with these ligands shows 1: 1 complex formation. The formation of complexes has been studied by Job's variation method. The values of conditional stability constants of Cu(II) complexes are greater than the corresponding Ni(II) complexes. The greater value of stability constant of Cu(II) complexes may be due to the fact of more stable nature of Cu(II). The value of stability constant of Cu(II) - Ligand 2 complex is greater than that of Cu(II)-Ligand 1 and Cu(II)-Ligand 3. The same of Ni(II)-Ligand 3 complex is greater than that of Ni(II)-Ligand 1 and Ni(II)-Ligand 2.

[Diaquo{bis(p-hydroxybenzoato-κ1O1)}(1-methylimidazole- κ1N1)}copper(II)]: Synthesis, crystal structure, catalytic activity and DFT study

Metal-organic hybrid complexes often exhibit large surface area, pore volume, fascinating structures and potential applications including catalytic applications. Hence a new metal-organic hybrid complex [Diaquo{bis(p-hydroxybenzoato-κ1O1)}(1-methylimidazole- κ1N1)}copper(II)] was synthesized using conventional method. Physico-chemical characterization of the complex was performed with FTIR spectroscopy, single crystal X-ray diffraction, TGA, EPR and FESEM. Single crystal X-ray diffraction study suggests it to be three dimensional with space group P212121 (orthorhombic). The crystal achieves its three-dimensional structure and stability through extensive intermolecular hydrogen bonding. Hirshfeld surface analysis, catalytic activity and DFT study of the complex was also performed. The synthesized complex acts as good catalyst in benzimidazole synthesis with good recyclability as catalyst up to 5th run.

Design, preparation, biological investigations and application of a benzoguanamine-based nickel complex for the synthesis of benzimidazoles

The new magnetic-supported benzoguanamine-based nickel complex was prepared, characterized by various procedures and used as a capable heterogeneous nano-catalyst for the synthesis of diverse 2-phenyl-1H-benzo[d]imidazoles from the reaction o-phenylenedia

Synthesis and evaluation of 2-aryl-1H-benzo[d]imidazole derivatives as potential microtubule targeting agents

Microtubule targeting agents (MTAs) are the potential drug candidates for anticancer drug discovery. Disrupting the microtubule formation or inhibiting the de-polymerization process by a synthetic molecule can lead to an excellent anticancer drug candidat

Tetrathienoanthracene-functionalized conjugated microporous polymers as an efficient, metal-free visible-light solid organocatalyst for heterogeneous photocatalysis

Owing to their advantages of superior inherent porosity, high chemical stability, light weight, and molecularly tunable optoelectronic properties, conjugated microporous polymers (CMPs) have been receiving increasing attention and research interest as pro

N-Alkylation of 2-Substituted Benzimidazole Derivatives and Their Evaluation as Antinemic Agents

Abstract: 2-Substituted benzimidazole derivatives were synthesized by condensation ofo-phenylenediamine with the correspondingsubstituted benzaldehydes and were alkylated at the nitrogen atom usingC3–C10 alkyl bromides in thepresence

Ionic liquid-immobilized hybrid nanomaterial: an efficient catalyst in the synthesis of benzimidazoles and benzothiazoles via anomeric-based oxidation

Abstract: In this study, a novel ionic liquid immobilized on silica-coated cobalt-ferrite magnetic nanoparticles. This novel hybrid nanostructure (CoFe2O4@SiO2@PAF-IL) was characterized by various microscopic and spectroscopic techniques including Fourier transformation infrared spectroscopy (FT–IR), X-ray powder diffraction (XRD), field emission scanning electron microscopy (SEM), the electron-dispersive X-ray spectroscopy (EDS), vibrating sample magnetometer (VSM), and thermogravimetric analysis (TGA/DTG). The catalytic activity of prepared nanomaterial was considered in the synthesis of the benzothiazole and benzimidazole derivatives. This method has several advantages such as good to excellent yields, short reaction times, solvent-free and environmentally-benign conditions, and simple work-up. Besides, nanocatalyst can be easily separated from the reaction mixture with the external magnetic field and reused several times without any loss of its catalytic activity. Graphic abstract: [Figure not available: see fulltext.].

Bandgap engineering in benzotrithiophene-based conjugated microporous polymers: a strategy for screening metal-free heterogeneous photocatalysts

Metal-free conjugated microporous polymers (CMPs) as visible-light active and recyclable photocatalysts offer a green and sustainable alternative to classical metal-based photosensitizers. However, the strategy for screening CMP-based heterogeneous photocatalysts has not been interpreted up to now. Herein, we present a general strategy for obtaining excellent solid photocatalysts, which is to implement bandgap engineering in the same series of materials. As a proof of concept, three conjugated porous materials containing benzo[1,2-b:3,4-b′:5,6-b′′]trithiophene building blocks (BTT-CMP1, BTT-CMP2 and BTT-CMP3) were successfully constructed. They possess permanent porosity with a large specific surface area and excellent stability. By changing the linker between benzotrithiophene units, the bandgaps, energy levels and photoelectric performances including the absorption, transient photocurrent responses and photocatalytic performances of BTT-CMPs could be handily modulated. Indeed, BTT-CMP2 displayed the best catalytic activity for visible-light-induced synthesis of benzimidazoles among the three CMP materials, even higher than that of small molecule photocatalysts. As a metal-free photocatalyst, interestingly, the screened BTT-CMP2 also showed extensive substrate applicability and outstanding recyclability. Additionally, we have the opinion that this strategy will prove to be a guiding principle for screening superior CMP-based photocatalysts and broaden their application fields.