65051-82-3

Basic information

• Product Name: Benzene, 1-(2-bromo-1-methylcyclopropyl)-4-methoxy-
• CAS NO: 65051-82-3
• Molecular Formula: C11H13BrO
• Molecular Weight: 241.128
• Mol File: 65051-82-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(2-bromo-1-methylcyclopropyl)-4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(2-bromo-1-methylcyclopropyl)-4-methoxy-(65051-82-3)
• EPA Substance Registry System: Benzene, 1-(2-bromo-1-methylcyclopropyl)-4-methoxy-(65051-82-3)

Safety Data

• Hazardous Substances Data: 65051-82-3(Hazardous Substances Data)

Upstream product

• 1712-69-2 1-isopropenyl-4-methoxybenzene 
• 52178-73-1 1-(2,2-dibromo-1-methylcyclopropyl)-4-methoxybenzene 

Downstream Products

• 65051-84-5 1-methoxy-4-(1-methylcycloprop-2-en-1-yl)benzene 

Relevant articles and documents

Synthesis of Functionalized α-Vinyl Aldehydes from Enaminones

An efficient RhII-catalyzed synthesis of functionalized α-vinyl aldehydes with high E/Z stereoselectivity was developed. The reaction mediates the cyclopropanation of enaminones with vinyl carbenoids that are generated from cyclopropenes in situ to give the aminocyclopropane intermediates. Selective C?C bond cleavage of the cyclopropane intermediates leads to formation of α-vinyl aldehyde derivatives with high E/Z selectivity. This method proceeds at room temperature under very mild reaction conditions and works with a broad substrate scope.

Asymmetric Nitrone Synthesis via Ligand-Enabled Copper-Catalyzed Cope-Type Hydroamination of Cyclopropene with Oxime

We report realization of the first enantioselective Cope-type hydroamination of oximes for asymmetric nitrone synthesis. The ligand promoted asymmetric cyclopropene "hydronitronylation" process employs a Cu-based catalytic system and readily available starting materials, operates under mild conditions and displays broad scope and exceptionally high enantio- and diastereocontrol. Preliminary mechanistic studies corroborate a CuI-catalytic profile featuring an olefin metalla-retro-Cope aminocupration process as the key C-N bond forming event. This conceptually novel reactivity enables the first example of highly enantioselective catalytic nitrone formation process and will likely spur further developments that may significantly expedite chiral nitrone synthesis.

Asymmetric Copper-Catalyzed Carbozincation of Cyclopropenes en Route to the Formation of Diastereo- and Enantiomerically Enriched Polysubstituted Cyclopropanes

The enantioselective synthesis of cyclopropylzinc reagents has been achieved via a copper-catalyzed carbozincation of 3,3-disubstituted cyclopropenes with diorganozinc reagents. The obtained organozinc compounds can be easily functionalized with a broad range of electrophiles, including palladium-catalyzed cross-couplings, affording highly substituted cyclopropanes. The operationally simple procedure using very low quantities of a commercially available and inexpensive copper catalyst provides a new tool for the synthesis of highly enantioenriched cyclopropanes as single diastereoisomers.