65057-56-9Relevant academic research and scientific papers
DOUBLE-HEADED PROTEASE INHIBITOR
-
Paragraph 1057; 1058, (2020/09/17)
The present invention provides a compound that is highly safe and useful in the prevention, alleviation, and/or treatment of various diseases involving enteropeptidase inhibition and/or trypsin inhibition, a pharmaceutical composition containing the compo
PARTIALLY SATURATED NITROGEN-CONTAINING HETEROCYCLIC COMPOUND
-
Paragraph 0596; 0597, (2015/06/17)
There are provided compounds having a superior PHD2 inhibitory effect that are represented by general formula (I'): (in the above-mentioned general formula (I'), W, Y, R2, R3, R4, and Y4 are as described hereinabove), or pharmaceutically acceptable salts thereof.
Synthesis of chemically functionalized superparamagnetic nanoparticles as delivery vectors for chemotherapeutic drugs
Hanessian, Stephen,Grzyb, Justyna A.,Cengelli, Feride,Juillerat-Jeanneret, Lucienne
, p. 2921 - 2931 (2008/09/20)
Superparamagnetic iron oxide nanoparticles (SPIONs) are in clinical use for disease detection by MRI. A major advancement would be to link therapeutic drugs to SPIONs in order to achieve targeted drug delivery combined with detection. In the present work,
Highly selective aldose reductase inhibitors. 3. Structural diversity of 3-(arylmethyl)-2,4,5-trioxoimidazolidine-1-acetic acids
Kotani, Takayuki,Nagaki, Yasuhiro,Ishii, Akira,Konishi, Yukari,Yago, Hisashi,Suehiro, Seishi,Okukado, Nobuhisa,Okamoto, Kaoru
, p. 684 - 694 (2007/10/03)
Accumulation of intracellular sorbitol, the reduced product of glucose, catalyzed by aldose reductase (AR) (EC 1.1.1.21), is thought to be the cause of the development of diabetic complications. Our attention is focused on finding compounds which inhibit
Synthesis of complex δ-acetylenic amino acids as potential multisubstrate adduct inhibitors of methyltransferases
Burns, Mark R.,Coward, James K.
, p. 1455 - 1470 (2007/10/03)
The synthesis of two types of δ-acetylenic amino acids is described. Key intermediates were derived from terminal acetylenes via two different routes: (1) palladium-mediated, Heck-type arylation, and (2) Simmons-Smith homologation followed by reaction of the resulting propargylic organometallic with a benzoyltrimethylsilane. Further elaboration to the desired amino acids involved the coupling of carbanions derived from N-benzylidene glycine esters to complex alkyl halides. The synthesis of nonnucleoside δ-acetylenic amino acids was successfully effected using this chemistry. In the case of the nucleoside-containing amino acids, a potential multisubstrate adduct: inhibitor of catechol O-methyltransferase was synthesized via this route. Unfortunately, the sensitivity to acid of 5'-deoxy, 5'-carbanucleosides prevented successful completion of the synthesis of a second nucleoside-containing δ-amino acid as a possible inhibitor of phenethanolamine N-methyltransferase.
