650598-43-9

Basic information

• Product Name: Benzoic acid, 2-bromo-4,6-dichloro-
• CAS NO: 650598-43-9
• Molecular Formula: C7H3BrCl2O2
• Molecular Weight: 269.91
• Mol File: 650598-43-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-bromo-4,6-dichloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-bromo-4,6-dichloro-(650598-43-9)
• EPA Substance Registry System: Benzoic acid, 2-bromo-4,6-dichloro-(650598-43-9)

Safety Data

• Hazardous Substances Data: 650598-43-9(Hazardous Substances Data)

Upstream product

• 650598-48-4 6-bromo-2,4-dichloro-3-(triethylsilyl)benzoic acid 
• 541-73-1 1,3-Dichlorobenzene 
• 650598-50-8 (4-bromo-2,6-dichlorophenyl)triethylsilane 
• 20776-63-0 2-amino-4,6-dichlorobenzoic acid 

Downstream Products

• 115615-21-9 2-bromo-4,6-dichlorobenzyl alcohol 
• 50-84-0 2,4 dichlorobenzoic acid 

Relevant articles and documents

2-OXOQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS

Disclosed herein are certain 2-oxoquinazoline derivatives of Formula (IA): (IA) that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.

Buttressing Effects Rerouting the Deprotonation and Functionalization of 1,3-Dichloro- and 1,3-Dibromobenzene

A systematic comparison between 1,3-difluorobenzene, 1,3-dichlorobenzene, and 1,3-dibromobenzene did not reveal major differences in their behavior towards strong bases such as lithium diisopropylamide or lithium 2,2,6,6-tetramethyl-piperidide. Thus, all 2,6-dihalobenzoic acids 1 are directly accessible by consecutive treatment with a suitable base and dry ice. In contrast, (2,6-dichlorophenyl)- and (2,6-bromo-phenyl)triethylsilane (2a and 2b) were found to undergo deprotonation at the 5-position (affording acids 3 and, after deprotection, 4), whereas the 1,3-difluoro analog is known to react at the 4-position. The 2,4-dihalobenzoic acids 7 were selectively prepared from either the silanes 2 (by bromination at the 4-position, metalation and carboxylation of the neighboring position, followed by desilylation and debromination) or the 1,3-dihalo-2-iodobenzenes 8 (by base-promoted migration of iodine to the 4-position followed by iodine/magnesium permutation and subsequent carboxylation). Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.