650600-16-1

Upstream product

• 593-56-6 N-methoxylamine hydrochloride 
• 1817-57-8 4-phenyl-3-butyne-2-one 

Downstream Products

• 16114-53-7 4-iodo-3-methyl-5-phenylisoxazole 
• 1008-75-9 3-methyl-5-phenylisoxazole 
• 1616956-25-2 4-fluoro-3-methyl-5-phenylisoxazole 
• 1006585-20-1 1,4-bis(3-fluorophenyl)buta-1,3-diyne 
• 1264282-76-9 1,4-bis(2,4-difluorophenyl)buta-1,3-diyne 
• 22666-07-5 di-p-tolylbutadiyne 
• 81022-98-2 3-methyl-5-phenyl-4-phenylethynylisoxazole 
• 886-66-8 1,4-diphenyl-1,3-butadiyne 
• 80221-17-6 1,4-bis(o-chlorophenyl)buta-1,3-diyne 

Relevant academic research and scientific papers

Isomerizable (: E / Z)-alkynyl- O -methyl oximes employing TMSCl-NCS in chlorinative cyclization for the direct synthesis of 4-chloroisoxazoles

For the first time, 4-chloroisoxazoles are directly synthesized in moderate to excellent yields from (E/Z)-alkynyl-O-methyl oximes via chlorinative cyclization. The synthesis employs the combination of N-chlorosuccinimide (NCS) and chlorotrimethylsilane (

Synthesis of 3,4,5-trisubstituted isoxazoles through gold-catalyzed cascade cyclization-oxidative alkynylation and cyclization-fluorination of 2-alkynone O-methyloximes

Gold-catalyzed tandem cyclization-oxidative alkynylation and cyclization-fluorination reactions of 2-alkynone O-methyloximes are described. The reactions proceed smoothly at room temperature in the presence of 10 mol % of (PPh3)AuNTf2, 2.5 equivalents of selectfluor, and 2 equivalents of K3PO4. 2-Alkynone O-methyloximes undergo intramolecular oxyauration/cyclization and ensuing oxidative cross-coupling and fluorination process to afford the corresponding 3,4,5-trisubstituted isoxazoles in a cascade manner.

Direct synthesis of 4-fluoroisoxazoles through gold-catalyzed cascade cyclization-fluorination of 2-alkynone O-methyl oximes

A tandem protocol for the synthesis of fluorinated isoxazoles has been developed via catalytic intramolecular cyclizations of 2-alkynone O-methyl oximes and ensuing fluorination. The reactions proceed smoothly at room temperature in the presence of 5 mol

The synthesis of highly substituted isoxazoles by electrophilic cyclization: An efficient synthesis of valdecoxib

(Chemical Equation Presented) A large number of functionally substituted 2-alkyn-1-one O-methyl oximes have been cyclized under mild reaction conditions in the presence of ICl to give the corresponding 4-iodoisoxazoles in moderate to excellent yields. The resulting 4-iodoisoxazoles undergo various palladium-catalyzed reactions to yield 3,4,5-trisubstituted isoxazoles, including valdecoxib.