650606-13-6

Basic information

• Product Name: 2-Propenenitrile, 2-(ethoxymethyl)-3-[4-(hexyloxy)phenyl]-, (2E)-
• Synonyms: 2-Propenenitrile,2-(ethoxymethyl)-3-[4-(hexyloxy)phenyl]-,(2E);(E)-3-(4-hexyloxyphenyl)-2-(ethoxymethyl)-2-propenenitrile
• CAS NO: 650606-13-6
• Molecular Formula: C18H25NO2
• Molecular Weight: 287.39700
• Mol File: 650606-13-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Propenenitrile, 2-(ethoxymethyl)-3-[4-(hexyloxy)phenyl]-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenenitrile, 2-(ethoxymethyl)-3-[4-(hexyloxy)phenyl]-, (2E)-(650606-13-6)
• EPA Substance Registry System: 2-Propenenitrile, 2-(ethoxymethyl)-3-[4-(hexyloxy)phenyl]-, (2E)-(650606-13-6)

Safety Data

• Hazardous Substances Data: 650606-13-6(Hazardous Substances Data)

Upstream product

• 5736-94-7 4-(hexyloxy)benzaldehyde 
• 2141-62-0 3-(ethoxy)propionitrile 
• 123-08-0 4-hydroxy-benzaldehyde 
• 638-45-9 1-Iodohexane 

Downstream Products

• 80407-61-0 5-(4-Hexyloxy-benzyl)-pyrimidine-2,4-diamine 

Relevant articles and documents

2,4-Diaminopyrimidines as inhibitors of leishmanial and trypanosomal dihydrofolate reductase

This paper describes the synthesis of 4′-substituted and 3′,4′-disubstituted 5-benzyl-2,4-diaminopyrimidines as selective inhibitors of leishmanial and trypanosomal dihydrofolate reductase. Compounds were then assayed against the recombinant parasite and human enzymes. Some of the compounds showed good activity. They were also tested against the intact parasites using in vitro assays. Good activity was found against Trypanosoma cruzi, moderate activity against Trypanosoma brucei and Leishmania donovani. Molecular modeling was undertaken to explain the results. The leishmanial enzyme was found to have a more extensive lipophilic binding region in the active site than the human enzyme. Compounds which bound within the pocket showed the highest selectivity.