65062-69-3Relevant academic research and scientific papers
Synthesis and Designation of the Diastereomeric Forms of Fully Protected 2'-Deoxyadenylyl-(3'-5')-2'-deoxyadenosine
Michels, Winfried,Schlimme, Eckhard
, p. 1398 - 1402 (2007/10/02)
The synthesis of the fully protected 2'-deoxyadenylyl-(3'-5')-2'-deoxyadenosine 3a is reported.Due to the chiral phosphotriester group 3a exists in two diasteromeric forms (3aA and 3aB) which could be distinguished by TLC and HPLC as well as 1H and 31P NMR spectroscopy.The absolute configuration as RP (3aA) and SP (3aB) is proposed on the basis of NMR data and chromatographic properties in combination with space filling models.
