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650628-07-2

4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-1-(3-methylphenyl)-, hydrazone is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 650628-07-2 Structure

  • Basic information

    1. Product Name: 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-1-(3-methylphenyl)-, hydrazone
    2. Synonyms:
    3. CAS NO:650628-07-2
    4. Molecular Formula: C12H12N6
    5. Molecular Weight: 240.267
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 650628-07-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-1-(3-methylphenyl)-, hydrazone(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-1-(3-methylphenyl)-, hydrazone(650628-07-2)
    11. EPA Substance Registry System: 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-1-(3-methylphenyl)-, hydrazone(650628-07-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 650628-07-2(Hazardous Substances Data)

650628-07-2 Usage

Potential anticancer activity

Works by inhibiting the enzyme poly(ADP-ribose) polymerase (PARP), leading to DNA damage in cancer cells

Ongoing research

Assessing its potential as a treatment for various types of cancer

Check Digit Verification of cas no

The CAS Registry Mumber 650628-07-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,5,0,6,2 and 8 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 650628-07:
(8*6)+(7*5)+(6*0)+(5*6)+(4*2)+(3*8)+(2*0)+(1*7)=152
152 % 10 = 2
So 650628-07-2 is a valid CAS Registry Number.

650628-07-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-hydrazino-1-(3-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidine

1.2 Other means of identification

Product number -
Other names (1-m-Tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-hydrazine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:650628-07-2 SDS

650628-07-2Downstream Products

650628-07-2Relevant articles and documents

Novel pyrazolopyrimidine derivatives as GSK-3 inhibitors

Peat, Andrew J.,Boucheron, Joyce A.,Dickerson, Scott H.,Garrido, Dulce,Mills, Wendy,Peckham, Jennifer,Preugschat, Frank,Smalley, Terrence,Schweiker, Stephanie L.,Wilson, Jayme R.,Wang, Tony Y.,Zhou, Huiqiang Q.,Thomson, Stephen A.

, p. 2121 - 2125 (2007/10/03)

A series of [1-aryl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]arylhydrazones were discovered as novel inhibitors glycogen synthase kinase-3 (GSK-3). Based on initial modeling a detailed SAR was constructed. Modification of the interior binding aryl ring (Ar1) determined this to be a tight binding region with little room for modification. As predicted from the model, a large variety of modifications could be incorporated into the hydrazone aryl ring. This work led to GSK-3 inhibitors in the low nano-molar range.

PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS

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Page 25-26, (2010/02/06)

The present invention relates generally to inhibitors of the kinases and more particularly to novel pyrazolopyrimidine compounds.

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