650629-04-2

Usage

Structure

Pyrazole derivative with a carbonitrile functional group and an amino group attached to a 3-ethoxyphenyl ring

Potential applications

Pharmaceutical industry (development of new drugs and medicinal compounds)

Properties

Interesting structural and chemical properties, valuable building block for the synthesis of biologically active molecules

Importance

Unique structure and functional groups, target for further research and development in organic synthesis and drug discovery.

Upstream product

• 90434-59-6 (3-ethoxy-phenyl)-hydrazine 
• 123-06-8 Ethoxymethylenemalononitrile 

Downstream Products

• 650628-45-8 1-(3-ethoxy-phenyl)-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 650628-44-7 1-(3-ethoxyphenyl)-4-hydrazino-1H-pyrazolo[3,4-d]pyrimidine 
• 650628-46-9 4-chloro-1-(3-ethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine 

Relevant academic research and scientific papers

PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS

The present invention relates generally to inhibitors of the kinases and more particularly to novel pyrazolopyrimidine compounds.

Novel pyrazolopyrimidine derivatives as GSK-3 inhibitors

A series of [1-aryl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]arylhydrazones were discovered as novel inhibitors glycogen synthase kinase-3 (GSK-3). Based on initial modeling a detailed SAR was constructed. Modification of the interior binding aryl ring (Ar1) determined this to be a tight binding region with little room for modification. As predicted from the model, a large variety of modifications could be incorporated into the hydrazone aryl ring. This work led to GSK-3 inhibitors in the low nano-molar range.