650635-68-0Relevant articles and documents
Synthesis and antifungal activity of 6-arylthio-/6-arylamino-4,7-dioxobenzothiazoles
Ryu, Chung-Kyu,Choi, Ko Un,Shim, Ju-Yeon,You, Hea-Jung,Choi, Ik Hwa,Chae, Mi Jin
, p. 4003 - 4008 (2007/10/03)
6-Arylthio-/6-arylamino-4,7-dioxobenzothiazoles were synthesized and tested for in vitro antifungal activity against Candida species and Aspergillus niger. 6-Arylamino-4,7-dioxobenzothiazoles 5 and 6 showed, in general, more potent antifungal activity than 6-arylthio-4,7-dioxobenzothiazoles 3 and 4. The 6-arylamino-substituted compounds 5 and 6 exhibited the greatest activity. In contrast, 6-arylthio-, 2-/5-methyl- or 5-methoxy-moieties of compounds 3-4 did not improve their antifungal activity significantly. The results of this study suggest that 6-arylamino-4,7-dioxobenzothiazoles would be potent antifungal agents.