650638-11-2 Usage
Structure
Benzimidazole derivative with a hydrazino group attached to the 4-position of the benzene ring
Industrial and pharmaceutical applications
Building block in the synthesis of various organic compounds, ligand in coordination chemistry, precursor to pharmaceuticals
Potential properties
Useful in biological research and drug development
Variation in properties and applications
May vary depending on specific uses and formulations
Check Digit Verification of cas no
The CAS Registry Mumber 650638-11-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,5,0,6,3 and 8 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 650638-11:
(8*6)+(7*5)+(6*0)+(5*6)+(4*3)+(3*8)+(2*1)+(1*1)=152
152 % 10 = 2
So 650638-11-2 is a valid CAS Registry Number.
650638-11-2Relevant articles and documents
Novel GSK-3 inhibitors with improved cellular activity
Peat, Andrew J.,Garrido, Dulce,Boucheron, Joyce A.,Schweiker, Stephanie L.,Dickerson, Scott H.,Wilson, Jayme R.,Wang, Tony Y.,Thomson, Stephen A.
, p. 2127 - 2130 (2004)
A novel series of [1-(1H-benzimidazol-7-yl)-1H-pyrazolo[3,4-d]pyrimidin-4- yl] arylhydrazones was synthesized and shown to potently inhibit glycogen synthase kinase-3 (GSK-3). In light of detailed structure-activity relationships and structural knowledge of the GSK-3 binding pocket, a benzimidazole substituent was incorporated onto the pyrazolopyrimidine core resulting in improved potency over previous analogs. More importantly, these derivatives show low nanomolar efficacy for stimulating glycogen synthesis in vitro and therefore may be useful in the treatment of type 2 diabetes mellitus.
