6507-10-4Relevant articles and documents
NOVEL SOLUBLE EPOXIDE HYDROLASE INHIBITORS AND METHOD OF USE THEREOF
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Page/Page column 43-44; 46, (2021/12/08)
Novel soluble epoxide hydrolase (sEH) inhibitors are provided, along with methods for their use. The soluble epoxide hydrolase inhibitors are useful in treating and/or preventing sEH-related related diseases, such as Alzheimer's disease and inflammation.
Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines
Lam, Thanh,Hilgers, Mark T.,Cunningham, Mark L.,Kwan, Bryan P.,Nelson, Kirk J.,Brown-Driver, Vickie,Ong, Voon,Trzoss, Michael,Hough, Grayson,Shaw, Karen Joy,Finn, John
, p. 651 - 668 (2014/03/21)
A new series of dihydrofolate reductase (DHFR) inhibitors, the 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines, were designed and optimized for antibacterial potency and enzyme selectivity. The most potent inhibitors in this series contained a five-membered