651-82-1

Upstream product

• 335-21-7 perfluoroethylperfluorocyclohexane 
• 43018-15-1 2-(Chloro-difluoro-methyl)-3,3-difluoro-2-pentafluorophenyl-oxirane 
• 652-22-2 octafluoroacetophenone 
• 392-56-3 Hexafluorobenzene 

Downstream Products

• 1997-38-2 2,3,5,6-Tetrafluor-4--toluol 
• 2392-36-1 2,3,5,6-Tetrafluor-4--anisol 
• 2377-89-1 1-pentafluoroethyl-2,3,5,6-tetrafluorobenzene 
• 2355-98-8 4-C₂F₅-C₆F₅NH₂ 
• 2251-57-2 perfluoro-(4-ethylphenyl)-hydrazine 
• 80308-96-9 perfluoro(1-ethylcyclohex-1-ene) 
• 1997-52-0 1-Ethyl-octadecafluor-4-methylcyclohexan 
• 25959-54-0 Trifluormethyl-bis-(pentafluor-phenyl)-carbinol 
• 51571-21-2 perfluoro-1,1-diphenylethane 

Relevant academic research and scientific papers

Selective mono-and diamination of polyfluorinated benzenes and pyridines with liquid ammonia

Amination of pentafluoropyridine, 2,3,5,6-tetrafluoropyridine, 4-chlorotetrafluoropyridine, 3,5-dichlorotrifluoropyridine, octafluorotoluene, α,α,α,2,3,5,6-heptafluorotoluene, decafluoro-m-xylene, decafluorobiphenyl, hexafluorobenzene, and pentafluorobenzene with liquid ammonia was investigated. Bis-aminodefluorination temperatures for the majority of substrates were shown to exceed significantly the corresponding temperatures of monoaminodefluorination. The optimal conditions for selective preparation of mono-and diaminopolyfluoro(het)arenes were elucidated. An efficient method for isolation of particular polyfluorophenylenediamines from product mixtures formed in nonselective reactions of pentafluorobenzene and hexafluorobenzene with aqueous ammonia based on complexation with a crown ether is proposed.

Oxygen replacement by fluorine in carbonyl derivatives of perfluoroaromatic compounds and isomerization of perfluoroindan-1,3-dione to perfluoro-3-methylenephthalide under the action of HF/SbF5

When acted upon by HF/SbF5 at 95 °C, carbonyl groups of perfluorinated acetophenone (10), 3,4-dihydronaphthalen-1(2H)-one (8), 2,3-dihydronaphthalene-1,4-dione (9), benzocyclobutenone (6), benzocyclobutenedione (7) and indan-1-one (1) are converted into difluoromethylene groups to give the corresponding perfluoroaromatic products. Perfluoroindan-2-one (5), under the same conditions, is transformed to bis(perfluoroindan-2-yl) ether (21). On heating with HF/SbF5, perfluoroindan-1,3-dione (2) isomerizes into perfluoro-3-methylenephthalide (4) at 95 °C, and gives 4,5,6,7-tetrafluoro-3-trifluoromethyl-phthalide (14) at 130 °C. Compound 4 in the absence of a solvent dimerizes giving perfluorodispiro[phthalide-3,1′-cyclobutane-2′,3″-phthalide] (18), and when heated with SbF5 at 130 °C, it is converted into perfluoro-3-methylphthalide (3). When acted upon by HF/SbF5 at 95 °C, perfluorinated benzoic acid (12) and phthalic anhydride (13) give the corresponding products with trifluoromethyl groups.