651013-90-0Relevant academic research and scientific papers
Chemoenzymatic synthesis and binding affinity of novel (R)- and (S)-3-aminomethyl-1-tetralones, potential atypical antipsychotics
Caro, Yolanda,Torrado, Maria,Masaguer, Christian F.,Ravina, Enrique,Padin, Fernando,Brea, Jose,Loza, Maria I.
, p. 585 - 589 (2007/10/03)
A series of (R)- and (S)-3-aminomethyl-1-tetralones, conformationally constrained analogues of haloperidol, have been obtained by enzymatic resolution of the corresponding racemic 3-hydroxymethyl-1-tetralones using Pseudomonas fluorescens lipase. Their bi
Kinetic resolution of 3-hydroxymethylbenzocycloalkanols by selective asymmetric hydrogen-transfer oxidation
Caro, Yolanda,Torrado, Maria,Masaguer, Christian F.,Ravina, Enrique
, p. 3689 - 3696 (2007/10/03)
Kinetic resolution of 3-hydroxymethylbenzocycloalkanols was performed by selective asymmetric hydrogen-transfer oxidation using the Ru(II)-(S,S)-TsDPEN catalyst. Thus, several 3-hydroxymethyl-1-tetralols 7a-d afforded (1R,3R)-3-hydroxymethyl-1-tetralols (
