651022-26-3

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-IODOBENZYL)PIPERIDINE is used as a building block for the synthesis of various pharmaceuticals for its versatile chemical structure and potential to create bioactive compounds.
Used in Agrochemical Industry:
1-(4-IODOBENZYL)PIPERIDINE is used as a precursor in the development of agrochemicals to enhance crop protection and yield.
Used in Organic Chemistry Research:
1-(4-IODOBENZYL)PIPERIDINE is used as a research compound to explore its unique structure and pharmacological properties, contributing to the advancement of organic chemistry.
Used in Medicinal Chemistry and Drug Development:
1-(4-IODOBENZYL)PIPERIDINE is used as a potential candidate in medicinal chemistry and drug development due to its unique structure and pharmacological properties, which may lead to the discovery of new therapeutic agents.

InChI:InChI=1/C12H16IN/c13-12-6-4-11(5-7-12)10-14-8-2-1-3-9-14/h4-7H,1-3,8-10H2

Upstream product

• 110-89-4 piperidine 
• 16004-15-2 1-bromomethyl-4-iodobenzene 
• 116772-67-9 (4-iodo-phenyl)-piperidin-1-yl-methanone 

Downstream Products

• 1428627-94-4 3,17β-bis(hydroxy)-7α-[6-(4-piperidin-1-ylmethyl-phenyl)-hex-5-ynyl]-estra-1,3,5(10)-triene 

Relevant academic research and scientific papers

Method for catalyzing hydrodesulfurization of thioamide derivative

The invention provides a method for catalyzing hydrodesulfurization of a thioamide derivative, which comprises the following steps: sequentially adding a pentacarbonyl manganese bromide catalyst, a reaction substrate thioamide derivative, Lewis acid, a solvent and alkali into a polytetrafluoroethylene lined reaction tube, putting the reaction tube into a high-pressure kettle, introducing hydrogen to carry out catalytic hydrogenation reaction, cooling to room temperature, discharging gas, washing the reaction tube with ethyl acetate, passing through a silica gel small short column, carrying out spin drying, and carrying out column chromatography purification to obtain a target product. The monovalent manganese which is low in toxicity and good in chemical selectivity and biocompatibility is used as the catalyst to catalyze hydrodesulfurization of the thioamide derivative, the substrate range is wide, the yield of amine is high, and the method has high drug synthesis application value.

Zinc-catalyzed chemoselective reduction of tertiary and secondary amides to amines

General and convenient procedures for the catalytic hydrosilylation of secondary and tertiary amides under mild conditions have been developed. In the presence of inexpensive zinc catalysts, tertiary amides are easily reduced by applying monosilanes. Key to success for the reduction of the secondary amides is the use of zinc triflate and disilanes with dual Si-H moieties. The presented hydrosilylations proceed with excellent chemoselectivity in the presence of sensitive ester, nitro, azo, nitrile, olefins, and other functional groups, thus making the method attractive for organic synthesis.

3-(4-PIPERIDINE-1YLMETHYL-PHENYL)-PROPION ACID-PHENYLAMIDE-DERIVATIVES AND RELATED COMPOUNDS USED IN THE FORM OF MCH ANTAGONISTS (MELANINE CONCENTRATING HORMONE) FOR TREATING EATING DISORDERS

The invention relates to amid compounds of general formula (I), wherein groups and residuals A, B, b, W, X, Y, Z, R1, R2 and R3 have significances given in a claim 1. In addition, said invention relates to drugs containing at least one type of inventive amid. Because of the antagonist activity of an MCH-receptor, the inventive drugs are suitable for treating metabolic disturbances and/or eating disorders, in particular adiposity, bulimia, anorexia, hyperphagia and diabetes.

PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED ANILINE AND DIPHENYLAMINE ANALOGS

PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula (I): wherein R1, R2 R 3 and R4 are as defined herein.