651027-20-2

Upstream product

• 98232-51-0 8-methoxy-3,4-dihydro-2H-benzo[b]oxepin-5-one 
• 41214-27-1 4-(3-methoxy-phenoxy)-butyric acid 
• 1352658-16-2 (E)-5-[4-(benzyloxy)benzylidene]-7-chloro-8-methoxy-2,3,4,5-tetrahydrobenzo[b]oxepine 
• 1352658-17-3 4-[(7-chloro-8-methoxy-2,3,4,5-tetrahydrobenzo[b]oxepin-5-yl)methyl]phenol 
• 1352658-12-8 5-chloro-4-methoxy-2-(trimethylsilyl)phenyl triflate 
• 1352658-13-9 1-(benzyloxy)-4-(bromoethynyl)benzene 
• 1352658-14-0 1-{5-[4-(benzyloxy)phenyl]pent-4-ynyloxy}-2-bromo-4-chloro-5-methoxybenzene 
• 1352658-15-1 (Z)-2,2'-{1-[4-(benzyloxy)phenyl]-5-(2-bromo-4-chloro-5-methoxyphenoxy)pent-1-ene-1,2-diyl}bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) 
• 651027-16-6 1-cyano-3-(3-methoxyphenoxy)propane 
• 3245-40-7 1-bromo-3-(3-methoxyphenoxy)propane 
• 57052-73-0 ethyl 4-(3-methoxyphenoxy)butanoate 
• 150-19-6 O-methylresorcine 

Relevant academic research and scientific papers

Three-component coupling of arynes and organic bromides

Magic trio: Arynes are easily coupled with neutral nucleophiles and organic bromides to afford functionalized bromoarenes depending upon the nucleophile (Nu). The three-component coupling proceeds through the formation of bromine ate complexes, and can be applied to the synthesis of multisubstituted isoquinolines and benzo[b]oxepines having pharmacological activity. Copyright

Structure-based drug design: Synthesis, crystal structure, biological evaluation and docking studies of mono- and bis-benzo[b]oxepines as non-steroidal estrogens

Mono- and bis-benzo[b]oxepine derivatives have been rationally synthesized to meet the molecular requirement for interaction with estrogen receptor. Bis-benzo[b]oxepines (7 and 9) and mono-benzo[b]oxepine (10) acquire geometry with phenolic groups disposed in a fashion to stimulate estrogen receptor. Structure-based investigation, in vivo activity and docking studies have been described and correlated to demonstrate a practical approach for suitable ligand design.