65117-54-6

Upstream product

• 108-24-7 acetic anhydride 
• 20404-06-2 Diazomethane 
• 118824-94-5 2',4'-Dihydroxy-3'-methyl-5'-nitroacetophenone 
• 118824-98-9 4'-Hydroxy-2'-methoxy-3'-methyl-5'-nitroacetophenone 
• 118824-97-8 4'-Hydroxy-2'-methoxy-3'-methylacetophenone 
• 118824-96-7 4'-Benzyloxy-2'-methoxy-3'-methylacetophenone 

Downstream Products

• 118825-00-6 6-Methoxy-2,5-bis(methoxymethoxy)-3-nitrotoluene 
• 118825-02-8 3-Amino-6-methoxy-2,5-bis(methoxymethoxy)toluene 
• 118825-03-9 (2-Amino-5-methoxy-3,6-bis-methoxymethoxy-4-methyl-phenyl)-methylsulfanyl-acetic acid ethyl ester 

Relevant academic research and scientific papers

Aryl radical cyclisation approach to highly substituted oxindoles related to mitomycins

Radical cyclisation of the hexa-substituted aromatic compounds 8 and 17 leads to highly substituted oxindoles 9 and 18 respectively in excellent yields. Oxindole 18 carries the correct substitution pattern for ring-A of mitomycin A.

Synthesis of Indolin-2-ones (Oxindoles) Related to Mitomycin A

Oxindoles (indolin-2-ones) containing the functionality of the first two rings of the mytomicin A structure have been synthesized.Attempts to employ the oxindole grouping to construct the third ring were unsuccessful because of the resistance of the oxindole group or its derivatives towards nucleophilic attack.An unusual methylation of 3-methyl-5-nitrobenzene-1,2,4-triol to give the (E)-3,6-dihydroxy-2-methyl-1,4-benzoquinone 4-methoxyimine N-oxide is noted.A novel indole formation is described.