65126-85-4

Usage

Uses

Used in Pharmaceutical Research:
3-(3-(trifluoroMethyl)phenyl)prop-2-yn-1-ol is used as a building block for the preparation of various bioactive molecules. Its unique properties and reactivity make it a valuable intermediate in the production of diverse chemical compounds.
Used in Organic Synthesis:
3-(3-(trifluoroMethyl)phenyl)prop-2-yn-1-ol is used as a key intermediate in the synthesis of complex organic molecules, contributing to the development of new chemical entities.
Used in Agrochemical Industry:
3-(3-(trifluoroMethyl)phenyl)prop-2-yn-1-ol may have potential applications in the agrochemical industry, where its unique properties can be utilized for the development of novel agrochemicals.
Used in Material Science Industry:
3-(3-(trifluoroMethyl)phenyl)prop-2-yn-1-ol may also have potential applications in the material science industry, where its unique properties can be employed for the development of new materials with specific characteristics.

Upstream product

• 401-81-0 m-trifluoromethylphenyl iodide 
• 107-19-7 propargyl alcohol 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 50-00-0 formaldehyd 
• 705-28-2 1-ethynyl-3-trifluoromethylbenzene 

Downstream Products

• 1453164-34-5 1-(3-azidoprop-1-yn-1-yl)-3-(trifluoromethyl)benzene 
• 1188541-66-3 1-propyl-8-{1-[3-(3-trifluoromethylphenyl)prop-2-ynyl]-1H-pyrazol-4-yl}-3,7-dihydropurine-2, 6-dione 
• 1188540-86-4 8-{1-[3-(3-trifluoromethylphenyl)prop-2-ynyl]-1H-pyrazol-4-yl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione 
• 364782-34-3 cinacalcet hydrochloride 
• 21172-41-8 3-[3-(trifluoromethyl)phenyl]propanal 
• 226256-56-0 cinacalcet 
• 78573-45-2 3-[3-(trifluoromethyl)phenyl]propan-1-ol 
• 1122474-47-8 (S)-5-(3-(trifluoromethyl)benzyl)-3-isopropyl-4-tosyl-3,4-dihydro-2H-1,4-oxazine 
• 1122474-56-9 (S)-5-(3-(trifluoromethyl)benzyl)-3-methyl-4-tosyl-3,4-dihydro-2H-1,4-oxazine 

Relevant academic research and scientific papers

Synthesis of Azepino[1,2-a]indole-10-amines via [6+1] Annulation of Ynenitriles with Reformatsky Reagent

Lewis acid-catalyzed [6+1] annulation reactions of 2-cyano-1-propargyl- and 2-alkynyl-1-cyanomethyl-indoles with Reformatsky reagent are described. 8-Aryl, 8-alkyl-, 8-hetaryl-, 9-aryl, and 9-alkyl-azepino[1,2-a]indole amines were obtained through a 7-endo-mode cyclization of the β-aminoacrylate intermediates. The antiproliferative activity of the azepino[1,2-a]indoles analogs against the HCT-116 cells were also examined.

Development of a telescoped flow process for the safe and effective generation of propargylic amines

Propargylic amines are important multifunctional building blocks that are frequently exploited in the synthesis of privileged heterocyclic entities. Herein we report on a novel flow process that achieves the safe and effective on-demand synthesis of propargylic amines in a telescoped manner. This process minimizes exposure to hazardous azide intermediates and renders a streamlined route into these building blocks. The value of this approach is demonstrated by the rapid generation of a small selection of drug-like thiazolines that result from a high-yielding reaction cascade between propargylic amines with different aryl isothiocyanates.

Catalyst-Free Annulation of 2-Pyridylacetates and Ynals with Molecular Oxygen: An Access to 3-Acylated Indolizines

A catalyst and additive-free annulation of 2-pyridylacetates and ynals under molecular oxygen was the first developed, affording 3-acylated indolizines in good to excellent yields. Molecular oxygen was used as the source of the carbonyl oxygen atom in indolizines. This approach was compatible with a wide range of functional groups, and especially it has been successfully extended to unsaturated double bonds and triple bonds, which were difficult to prepare by previous methods in a single step.

Metal-free aminothiation of alkynes: Three-component tandem annulation toward indolizine thiones from 2-alkylpyridines, ynals, and elemental sulfur

A metal-free three-component annulation reaction for the synthesis of indolizine thiones via tandem C-C/C-N/C-S bond formation was developed. Various 2-alkylpyridines with aromatic ynals and elemental sulfur proceeded smoothly under catalyst-free conditions, and the desired products were obtained in moderate to excellent yields.

Synthesis of α-Substituted Primary Benzylamines through Copper-Catalyzed Cross-Dehydrogenative Coupling

A copper-catalyzed route to α-substituted, primary benzylamines by C-H functionalization of alkylarenes is described. The method directly affords the amine hydrochloride salt. Catalyst loadings down to 0.1 mol % in combination with scalability, insensitivity to air and moisture, and no need for column chromatography makes the procedure highly practical. The facile synthesis of the racemate of a blockbuster drug highlights the relevance for the development of pharmaceuticals. Preliminary mechanistic data are also included.

Design and synthesis of novel xanthine derivatives as potent and selective A2B adenosine receptor antagonists for the treatment of chronic inflammatory airway diseases

Adenosine induces bronchial hyperresponsiveness and inflammation in asthmatics through activation of A2B adenosine receptor (A2BAdoR). Selective antagonists have been shown to attenuate airway reactivity and improve inflammatory cond

Copper-Catalyzed Enantio-, Diastereo-, and Regioselective [2,3]-Rearrangements of Iodonium Ylides

The first highly enantioselective, diastereoselective, and regioselective [2,3]-rearrangement of iodonium ylides has been developed as a general solution to catalytic onium ylide rearrangements. In the presence of a chiral copper catalyst, substituted allylic iodides couple with α-diazoesters to generate metal-coordinated iodonium ylides, which undergo [2,3]-rearrangements with high selectivities (up to >95:5 r.r., up to >95:5 d.r., and up to 97 % ee). The enantioenriched iodoester products can be converted stereospecifically into a variety of onium ylide rearrangement products, as well as compounds that are not accessible by classical onium ylide rearrangements.

Synthesis of 3-benzylisoquinolines by domino imination/cycloisomerisation of 2-propargylbenzaldehydes

An easy entry to uncommon 2-propargylbenzaldehydes was developed. 2-Propargylbenzaldehydes demonstrated to be suitable building blocks for the synthesis of 3-benzyl isoquinolines by microwave promoted domino imination/cycloisomerisation in the presence of

A process for the preparation of cinacalcet and intermediates thereof

The present invention relates to a process for the preparation of (R)-(1-Naphthalen-1-yl-ethyl)-[3-(3-trifluoromethyl-phenyl)-propyl]-amine or a salt thereof, in particular the hydrochloride, and intermediates useful in its synthesis.

PROCESS FOR THE PREPARATION OF CINACALCET AND INTERMEDIATES THEREOF

The present invention relates to a process for the preparation of (R)-(1-Naphthalen-1-yl-ethyl)-[3-(3-trifluoromethyl-phenyl)-propyl]-amine or a salt thereof, in particular the hydrochloride, and intermediates useful in its synthesis.