65126-85-4

Basic information

• Product Name: 3-(3-(trifluoroMethyl)phenyl)prop-2-yn-1-ol
• Synonyms: 3-(3-(trifluoroMethyl)phenyl)prop-2-yn-1-ol
• CAS NO: 65126-85-4
• Molecular Formula: C₁₀H₇F₃O
• Molecular Weight: 200.1571896
• Mol File: 65126-85-4.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(3-(trifluoroMethyl)phenyl)prop-2-yn-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-(trifluoroMethyl)phenyl)prop-2-yn-1-ol(65126-85-4)
• EPA Substance Registry System: 3-(3-(trifluoroMethyl)phenyl)prop-2-yn-1-ol(65126-85-4)

Safety Data

• Hazardous Substances Data: 65126-85-4(Hazardous Substances Data)

Usage

General Description

3-(3-(trifluoromethyl)phenyl)prop-2-yn-1-ol is a chemical compound with the molecular formula C10H7F3O. It is a derivative of phenylpropynol, with a trifluoromethyl group attached to the phenyl ring. 3-(3-(trifluoroMethyl)phenyl)prop-2-yn-1-ol is commonly used in organic synthesis and pharmaceutical research as a building block for the preparation of various bioactive molecules. It may also have potential applications in agrochemical and material science industries. The trifluoromethyl group contributes to the compound's unique properties and reactivity, making it a valuable intermediate in the production of diverse chemical compounds.

Upstream product

• 401-81-0 m-trifluoromethylphenyl iodide 
• 107-19-7 propargyl alcohol 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 50-00-0 formaldehyd 
• 705-28-2 1-ethynyl-3-trifluoromethylbenzene 

Downstream Products

• 1453164-34-5 1-(3-azidoprop-1-yn-1-yl)-3-(trifluoromethyl)benzene 
• 1188541-66-3 1-propyl-8-{1-[3-(3-trifluoromethylphenyl)prop-2-ynyl]-1H-pyrazol-4-yl}-3,7-dihydropurine-2, 6-dione 
• 1188540-86-4 8-{1-[3-(3-trifluoromethylphenyl)prop-2-ynyl]-1H-pyrazol-4-yl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione 
• 364782-34-3 cinacalcet hydrochloride 
• 21172-41-8 3-[3-(trifluoromethyl)phenyl]propanal 
• 226256-56-0 cinacalcet 
• 78573-45-2 3-[3-(trifluoromethyl)phenyl]propan-1-ol 
• 1122474-47-8 (S)-5-(3-(trifluoromethyl)benzyl)-3-isopropyl-4-tosyl-3,4-dihydro-2H-1,4-oxazine 
• 1122474-56-9 (S)-5-(3-(trifluoromethyl)benzyl)-3-methyl-4-tosyl-3,4-dihydro-2H-1,4-oxazine 

Relevant articles and documents

Synthesis of Azepino[1,2-a]indole-10-amines via [6+1] Annulation of Ynenitriles with Reformatsky Reagent

Lewis acid-catalyzed [6+1] annulation reactions of 2-cyano-1-propargyl- and 2-alkynyl-1-cyanomethyl-indoles with Reformatsky reagent are described. 8-Aryl, 8-alkyl-, 8-hetaryl-, 9-aryl, and 9-alkyl-azepino[1,2-a]indole amines were obtained through a 7-endo-mode cyclization of the β-aminoacrylate intermediates. The antiproliferative activity of the azepino[1,2-a]indoles analogs against the HCT-116 cells were also examined.

Catalyst-Free Annulation of 2-Pyridylacetates and Ynals with Molecular Oxygen: An Access to 3-Acylated Indolizines

A catalyst and additive-free annulation of 2-pyridylacetates and ynals under molecular oxygen was the first developed, affording 3-acylated indolizines in good to excellent yields. Molecular oxygen was used as the source of the carbonyl oxygen atom in indolizines. This approach was compatible with a wide range of functional groups, and especially it has been successfully extended to unsaturated double bonds and triple bonds, which were difficult to prepare by previous methods in a single step.

Synthesis of α-Substituted Primary Benzylamines through Copper-Catalyzed Cross-Dehydrogenative Coupling

A copper-catalyzed route to α-substituted, primary benzylamines by C-H functionalization of alkylarenes is described. The method directly affords the amine hydrochloride salt. Catalyst loadings down to 0.1 mol % in combination with scalability, insensitivity to air and moisture, and no need for column chromatography makes the procedure highly practical. The facile synthesis of the racemate of a blockbuster drug highlights the relevance for the development of pharmaceuticals. Preliminary mechanistic data are also included.