65130-27-0Relevant academic research and scientific papers
Organic long-afterglow compound, and preparation method and application thereof
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Paragraph 0076-0080, (2020/02/14)
The invention discloses an organic long-afterglow compound, and a preparation method and application thereof, and belongs to the technical field of photodynamic therapy. According to the invention, the long-afterglow compound with a brand-new structure is designed and synthesized on the basis of oxygen group elements. The long-afterglow compound has the following advantages: 1, the imaging time islong, and nanosecond-grade imaging of traditional fluorescent imaging agents is improved to millisecond-imaging of the organic long-afterglow material; 2, the oxygen group elements are introduced into the long-afterglow compound, so that the yield of triplet excitons of molecules is introduced, and generation of reactive oxygen is promoted; 3, the excitation range of the long-afterglow compound can be extended to visible light, and the long-afterglow compound can easily achieve a good therapeutic effect under visible light irradiation and has low biological toxicity; and 4, the long-afterglowcompound has good biocompatibility. According to the invention, experiments prove that the compound has obvious inhibitory activity on Gram-positive bacteria, and thus the compound has a potential for being used as a photosensitizer for effective photodynamic therapy.
Selenium dioxide promoted dinitrogen extrusion/direct selenation of arylhydrazines and anilines
Yaqoob Bhat, Mohammad,Kumar, Atul,Naveed Ahmed, Qazi
supporting information, (2020/03/19)
A novel, efficient, economical strategy for the coupling and direct selenation of arylhydrazines to selenides using SeO2 has been developed. Our method employs SeO2 as the selenium source with hydrazines as coupling reactants to generate selenides via dinitrogen extrusion. This reagent also helped to generate ArSe substitued aniline derivatives via C–H functionalization reaction in good yields. The application of this method in gram scale was also carried out.
Ullmann-type C-Se Cross-Coupling in the Hydantoin Family: Synthesis, Mechanistic Studies, and Tests of Biological Activity
Beloglazkina, Elena K.,Finko, Alexander V.,Laikov, Dimitri N.,Majouga, Alexander G.,Skvortsov, Dmitry A.,Tafeenko, Victor A.,Vyhivskyi, Oleksandr,Zhirkina, Irina V.,Zyk, Nikolay V.
, p. 3160 - 3173 (2020/03/23)
An attractive strategy for C-Se bond formation by Ullmann-type copper(I)-promoted cross-coupling is developed. A wide range of aryliodides reacts with various disubstituted 2-selenohydantoins under mild conditions and provides Se-arylated imidazolines in moderate to high yields. Computational mechanistic studies show the oxidative addition/intramolecular reductive elimination likely to be the lowest-energy pathway. Cytotoxic activity of all 43 reaction products has been tested in vitro against MCF7 and A549 cancer cell lines with VA13 and MCF10a control cells.
Selenacalix[4]dithienothiophene: Synthesis, Structure, and Complexation of a Cyclic Tetramer of Selenide-Bridging Dithienothiophene
Hasegawa, Masashi,Takahashi, Kazuhiro,Inoue, Ryota,Haga, Shiori,Mazaki, Yasuhiro
supporting information, p. 1647 - 1650 (2018/09/21)
An efficient cyclization toward a cyclic tetramer of dithienothiophene (DTT) linked by divalent selenium atoms has been developed via palladium-catalyzed coupling reaction of (nBu3Sn)2Se. X-ray analysis revealed its highly symmetrical structure had an alternate arrangement of DTT units. There are several Se???π interactions forming a supramolecular network leading to large void channel space. The cyclic tetramer possesses moderate electron-donating ability. Furthermore, the cyclic tetramer undergoes complexation with C60 in a 1:2 ratio in the solid state to give a highly symmetrical three-dimensional array of C60.
Synthesis of Diaryl Selenides via Palladium-Catalyzed Debenzylative Cross-Coupling of Aryl Benzyl Selenides with Aryl Bromides
Wang, Hao,Chen, Shuguang,Liu, Guoqing,Guan, Haixing,Zhong, Daoyin,Cai, Jun,Zheng, Zhipeng,Mao, Jianyou,Walsh, Patrick J.
supporting information, p. 4086 - 4091 (2018/11/21)
Herein, we report a novel method for synthesizing diaryl selenides from aryl benzyl selenides and aryl bromides via debenzylative cross-coupling with a Pd/NIXANTPHOS-catalyst. NIXANTPHOS outperformed other commonly used bi- and monodentate ligands examined in this novel transformation. This reaction system displays wide functional group tolerance and excellent substrate scope. The transformation broadens the scope of palladium-catalyzed debenzylative processes to use selenolate anions as a leaving group. Its potential for practical synthetic applications was demonstrated with the gram scale synthesis of 4-chlorophenyl phenyl selenide.
Potassium selenocyanate as an efficient selenium source in C-Se cross-coupling catalyzed by copper iodide in water
Kumar, A. Vijay,Reddy, V. Prakash,Reddy, C. Suresh,Rao, K. Rama
supporting information; experimental part, p. 3978 - 3981 (2011/08/09)
An efficient and conceptually new protocol for C-Se cross coupling of potassium selenocyanate with aryl halides via copper-catalyzed cascade reaction has been developed in water. Utilizing this protocol, a variety of aryl and heteroaryl halides were reacted with potassium selenocyanate to afford the corresponding diaryl selenides in moderate to good yields.
