651312-17-3Relevant academic research and scientific papers
Synthesis of N-Protected 3,3-Difluoroazetidin-2-ones
Lacroix, Simon,Cheguillaume, Arnaud,Gerard, Stephane,Marchand-Brynaert, Jacqueline
, p. 2483 - 2486 (2007/10/03)
Representative N-protected 3,3-difluoroazetidin-2-ones 3 were obtained, either in one step by cycloaddition of zinc enolate 1 derived from ethyl bromodifluoroacetate onto N,N′,N″-trisubstituted hexahydro-1,3,5-triazines 2 (Schiff base trimer) in the case of 3a [N-(p-methoxybenzyl) derivative], or in two steps consisting of a Reformatsky-type reaction for the preparation of N-substituted 3-amino-2,2-difluoropropanotes 8 followed by N1-C2 cyclization under basic conditions in the cases of 3b (N-anisyl derivative) and 3c (N-benzhydryl derivative).
