651315-44-5

Basic information

• Product Name: 2(1H)-Quinolinone,3-ethyl-3,4-dihydro-6-nitro-(9CI)
• Synonyms: 2(1H)-Quinolinone,3-ethyl-3,4-dihydro-6-nitro-(9CI)
• CAS NO: 651315-44-5
• Molecular Formula: C11H12N2O3
• Molecular Weight: 220.22458
• Product Categories: ETHYL
• Mol File: 651315-44-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2(1H)-Quinolinone,3-ethyl-3,4-dihydro-6-nitro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinolinone,3-ethyl-3,4-dihydro-6-nitro-(9CI)(651315-44-5)
• EPA Substance Registry System: 2(1H)-Quinolinone,3-ethyl-3,4-dihydro-6-nitro-(9CI)(651315-44-5)

Safety Data

• Hazardous Substances Data: 651315-44-5(Hazardous Substances Data)

Usage

Synonym

3-Ethyl-3,4-dihydro-6-nitro-2(1H)-quinolinone

Chemical Family

Quinolinone

Core Structure

Quinolin-4(1H)-one

Characteristic Groups

Ethyl group, Nitro group

Usage

Pharmaceutical, Research applications

Ongoing Investigation

Properties and potential uses

Synthesis

Specific chemical reactions

Physical and Chemical Properties

Of interest to chemists and researchers in various fields.

Upstream product

• 553-03-7 3,4-dihydro-2(1H)-quinolone 
• 184042-18-0 3-ethyl-3,4-dihydro-2(1H)-quinolinone 

Relevant articles and documents

Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter: Part 3. A potential 5-HT transporter imaging agent, 3-(3-[18F]Fluoropropyl)-6-nitroquipazine

3-(3-[18F]Fluoropropyl)-6-nitroquipazine ([18F]FPNQ) as a 5-HT transporter imaging agents was designed, synthesized, and evaluated. FPNQ was selected due to its potent in vitro biological activity (K i=0.32 nM) in rat brain cortical membranes. The 18F- labeled FPNQ was prepared by reaction of the propyl mesylate as a precursor with tetra-n-butylammonium [18F]fluoride generated under NCA conditions. The precursor mesylate was synthesized from commercially available hydrocarbostyril in nine steps in 21% overall yield. The specific activity of the [18F]FPNQ determined by radioreceptor assay was 27.0 GBq/μmol. Tissue distribution studies in mice showed the highest uptake in the frontal cortex (5.79%ID/g) at 60 min post-injection.