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Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2(1H)-Pyrimidinone, 4,5,6-trimethyl(9CI) is used as a building block in the synthesis of pharmaceuticals and agrochemicals. Its unique structure allows it to be a versatile component in the development of new drugs and agrochemicals with potential therapeutic and pesticidal properties.
Used in Research and Development:
Due to its potential biological and pharmacological activities, 2(1H)-Pyrimidinone, 4,5,6-trimethyl(9CI) is used in research and development for exploring its properties and applications. This may include studying its interactions with biological systems, evaluating its efficacy in treating diseases, and assessing its potential as a lead compound in drug discovery.

Upstream product

• 859950-06-4 1,5,9-trimethyl-2,4,6,8-tetraaza-bicyclo[3.3.1]nonane-3,7-dione 
• 815-57-6 3-Methyl-2,4-pentanedione 
• 57-13-6 urea 

Relevant academic research and scientific papers

Nitrogen-containing heterocycles from metal β-diketonates

Factors determining the reaction of metal β-diketonates with hydrazine, in particular the nature of central metal ion and structure of β-diketonate ligand, are discussed. The possibility for the preparation of other heterocyclic compounds via reaction of metal acetylacetonates with phenylhydrazine, o-phenylenediamine, urea, and thiourea was studied.

Piperazinylalkylpyrimidines as hypoglycemic agents

Novel hypoglycemic agents having the formula (I) are disclosed. STR1

Six pyrimidonium salts: determination of their crystal structures and studies of their prototropic behaviour in solution

Six methyl-substituted 2-pyrimidonium chloride salts have been prepared and the rates of hydrogen exchange of their reactive methyl groups (at the 4- and 6- positions) have been determined in DCl/D2O solution.Adjacent methyl groups, whether on nitrogen or carbon, activate the exchanging centres, whereas more distant methyl groups have a deactivating effect.The molecular geometry of the salts has been determined by X-ray crystallography with the view to determining whether the presence of strain in the pyrimidonium ring can account for the activating effect of adjacent methyl.The most reactive compound, the 1,5,6-trimethylpyrimidonium chlride, has a geometry that is consistent with high reactivity, viz. a non-planar ring and short H...H intermethyl distance.However, the 1,4,5,6-tetramethyl compound, which also is nonplanar and has an extremely short 5-6 intermethyl distance (1.99 Angsroem), is not highly reactive; that is, the heightened strain is unable to overcome the deactivating inductive effect of the additional methyl group.We conclude that deviations from ring planarity and short intermethyl distances are insufficient to account for the activation produced by adjacent methyl though they appear to be contributing factors to this effect.

Echange isotopique hydrogene-deuterium subi par les groupements methyles de la trimethyl-4,5,6 pyrimidone-2

The rate of deuterium exchange of 4 and 6 methyl protons in 4,5,6-trimethyl-2-pyrimidone has been followed in D2O over a range of acidity from pD 0.4 to 7.7 by means of proton magnetic resonance spectroscopy.The maximum of exchange rate represents equimolar proportions of the pyrimidone and its conjugate acid.The maximum is due to the neutral molecule acting as a base and removing a proton from one of the methyl groups of its conjugate acid.The exchange study of methyl protons in 1,4,5,6-tetramethyl-2-pyrimidone corroborates this mechanism.