65134-74-9 Usage
Uses
Used in Pharmaceutical Industry:
[S-(R,R)]-3,3'-Dithiobis[2-methylpropanoic acid] is used as an impurity in the production of Captopril, a medication that acts as a neuroprotective and neuroresearch product. Its presence in the synthesis process is crucial for the development and efficacy of Captopril as an ACE inhibitor, which is used to treat hypertension and heart failure.
Used in Research Applications:
In the field of scientific research, [S-(R,R)]-3,3'-Dithiobis[2-methylpropanoic acid] serves as a valuable compound for studying the properties and mechanisms of action of Captopril. Researchers can utilize this impurity to investigate the interactions between Captopril and its target enzymes, as well as to explore potential side effects and improvements in drug design.
Used in Quality Control:
[S-(R,R)]-3,3'-Dithiobis[2-methylpropanoic acid] plays a significant role in the quality control processes of pharmaceutical manufacturing. By monitoring the presence and concentration of this impurity in Captopril products, manufacturers can ensure the safety, efficacy, and consistency of the medication, adhering to regulatory standards and guidelines.
Check Digit Verification of cas no
The CAS Registry Mumber 65134-74-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,1,3 and 4 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 65134-74:
(7*6)+(6*5)+(5*1)+(4*3)+(3*4)+(2*7)+(1*4)=119
119 % 10 = 9
So 65134-74-9 is a valid CAS Registry Number.
65134-74-9Relevant academic research and scientific papers
Angiotensin converting enzyme inhibitors: N-substituted monocyclic and bicyclic amino acid derivatives
Stanton,Gruenfeld,Babiarz,Ackerman,Friedmann,Yuan,Macchia
, p. 1267 - 1277 (2007/10/02)
The synthesis of N-(3-mercaptopropionyl)-N-arylglycines (14a-x), -N-arylalanines (15a,b), -N-cycloalkylglycines (16a-k), and -1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids (17a-d), -1,2,3,4-tetrahydroquinoline-2-carboxylic acids (18a-f), and -indoline-2-carboxylic acids (19a-k) is described. In vitro inhibition of angiotensin converting enzyme (ACE) is reported for each compound, and the structure-activity relationship for each series is discussed. The in vivo inhibition of ACE and antihypertensive effects of representative compounds from each series are discussed. The most potent compound, 19d, had an in vitro ACE IC50 of 2.6 x 10-9 M and lowered blood pressure in spontaneous hypertensive rats 85 mm at a dose of 10 mg/kg po.
