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D-PHE-PRO-ARG-CHLOROMETHYLKETONE, also known as PPACK, is a chemical compound that serves as a potent inhibitor of serine proteases, including thrombin, trypsin, and plasmin. It is characterized by its ability to irreversibly bind to the active sites of these enzymes, thereby inhibiting their activity and preventing the cleavage of their substrates. This property makes PPACK a valuable tool in laboratory research for studying the physiological roles of serine proteases and their involvement in various biological processes.

65149-23-7

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65149-23-7 Usage

Uses

Used in Laboratory Research:
D-PHE-PRO-ARG-CHLOROMETHYLKETONE is used as a research tool for inhibiting serine proteases to study their physiological roles and mechanisms in blood coagulation, fibrinolysis, and other biological processes controlled by these enzymes.
Used in Pharmaceutical Development:
D-PHE-PRO-ARG-CHLOROMETHYLKETONE is used as a potential therapeutic agent for the treatment of thrombotic and inflammatory diseases. By modulating the activity of serine proteases, PPACK can help in managing the underlying pathophysiological processes associated with these conditions.
Used in Drug Design and Development:
In the pharmaceutical industry, D-PHE-PRO-ARG-CHLOROMETHYLKETONE serves as a lead compound for the development of new drugs targeting serine proteases. Its ability to irreversibly inhibit these enzymes can be leveraged to design drugs with improved efficacy and selectivity for the treatment of various diseases.
Used in Diagnostic Applications:
D-PHE-PRO-ARG-CHLOROMETHYLKETONE can be employed in diagnostic assays to detect the presence and activity of serine proteases in biological samples. This can aid in the diagnosis and monitoring of diseases associated with the dysregulation of these enzymes.

Check Digit Verification of cas no

The CAS Registry Mumber 65149-23-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,1,4 and 9 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 65149-23:
(7*6)+(6*5)+(5*1)+(4*4)+(3*9)+(2*2)+(1*3)=127
127 % 10 = 7
So 65149-23-7 is a valid CAS Registry Number.

65149-23-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S)-N-[(2S)-1-[[(3S)-1-chloro-6-(diaminomethylideneamino)-2-oxohexan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide

1.2 Other means of identification

Product number -
Other names Phe-pro-arg-CK

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:65149-23-7 SDS

65149-23-7Upstream product

65149-23-7Downstream Products

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