65149-23-7

Basic information

• Product Name: D-PHE-PRO-ARG-CHLOROMETHYLKETONE
• Synonyms: D-PHE-PRO-ARG-CHLOROMETHYLKETONE;D-PHE-PRO-ARG-CMK;PPACK;D-Phe-Pro-Age-cmk;phenylalanyl-prolyl-arginine-chloromethyl ketone
• CAS NO: 65149-23-7
• Molecular Formula: C21H31ClN6O3
• Molecular Weight: 450.96
• Mol File: 65149-23-7.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: D-PHE-PRO-ARG-CHLOROMETHYLKETONE(CAS DataBase Reference)
• NIST Chemistry Reference: D-PHE-PRO-ARG-CHLOROMETHYLKETONE(65149-23-7)
• EPA Substance Registry System: D-PHE-PRO-ARG-CHLOROMETHYLKETONE(65149-23-7)

Safety Data

• Hazardous Substances Data: 65149-23-7(Hazardous Substances Data)

Usage

General Description

D-PHE-PRO-ARG-CHLOROMETHYLKETONE, also known as PPACK, is a chemical compound that acts as a potent inhibitor of serine proteases, particularly thrombin, trypsin, and plasmin. It is often used in laboratory research to block the activity of these proteases and study their physiological roles. PPACK irreversibly binds to the active site of these enzymes, preventing them from cleaving their substrates and disrupting the normal function of the proteins they regulate. D-PHE-PRO-ARG-CHLOROMETHYLKETONE is an important tool for understanding the mechanisms of blood coagulation, fibrinolysis, and other biological processes that are controlled by serine proteases. Additionally, PPACK has potential therapeutic applications in the treatment of thrombotic and inflammatory diseases by modulating the activity of these enzymes.