6515-18-0

Basic information

• Product Name: 1-(2-MethoxyMethoxy-phenyl)-ethanone
• Synonyms: 1-(2-MethoxyMethoxy-phenyl)-ethanone
• CAS NO: 6515-18-0
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.20048
• Mol File: 6515-18-0.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 139-140 °C(Press: 12.5 Torr)
• Appearance: /
• Density: 1.073±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(2-MethoxyMethoxy-phenyl)-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-MethoxyMethoxy-phenyl)-ethanone(6515-18-0)
• EPA Substance Registry System: 1-(2-MethoxyMethoxy-phenyl)-ethanone(6515-18-0)

Safety Data

• Hazardous Substances Data: 6515-18-0(Hazardous Substances Data)

Usage

General Description

1-(2-MethoxyMethoxy-phenyl)-ethanone, also known as MOP, is a chemical compound with the molecular formula C10H12O3. It is a pale yellow liquid with a slightly sweet odor. MOP is commonly used as a flavoring agent in the food and beverage industry, as well as a fragrance ingredient in perfumes and cosmetics. It is also used as a solvent and in the synthesis of organic compounds. In addition, MOP has potential pharmaceutical applications due to its antimicrobial and antioxidant properties. However, it should be handled with caution as it may cause skin and eye irritation, and can be harmful if ingested or inhaled.

Upstream product

• 109-87-5 Dimethoxymethane 
• 118-93-4 o-hydroxyacetophenone 
• 824-91-9 O-methoxymethylphenol 
• 108-24-7 acetic anhydride 
• 107-30-2 chloromethyl methyl ether 
• 699-83-2 2,6-dihydroxylacetophenone 

Downstream Products

• 90618-63-6 1-(2-methoxymethoxybenzoyl)-3-(2-methyl-1,3-dioxolan-2-yl)propan-2-ol 
• 93878-18-3 4-methoxy-2'-methoxymethoxychalcone 
• 35095-60-4 2'-Methoxymethoxy-4-methoxy-chalcon 
• 76434-54-3 2',6'-bis(methoxymethoxy)acetophenone 
• 167558-59-0 1,1-Dichloro-2-propene 
• 167558-58-9 1,1-Dibromo-2-propene 
• 737767-18-9 (E)-1-(2-chloro-1-methylvinyl)-2-(methoxymethoxy)benzene 
• 1441180-48-8 4-ethoxy-2-(2-(methoxymethoxy)phenyl)but-3-yn-2-ol 
• 118-93-4 o-hydroxyacetophenone 

Relevant articles and documents

Sequential Energy Transfer Catalysis: A Cascade Synthesis of Angularly-Fused Dihydrocoumarins

An operationally simple one-pot protocol has been developed to enable the conversion of diversely substituted cinnamic acid derivatives into angularly-fused dihydrocoumarins (up to 94%). Inspired by coumarin biosynthesis, this reaction cascade harnesses photochemical E → Z alkene isomerization enabled by energy transfer catalysis using inexpensive thioxanthen-9-one (TX) under irradiation at 402 nm. Subsequent lactonization generates the heterocyclic core prior to a second photosensitization event to induce a [2 + 2] cycloaddition, again mediated by TX. The tetracyclic products are generated efficiently, and proof of the structure was established by X-ray crystallography. Mechanistic investigations, including structural probes and NMR reaction monitoring, support the postulated order of events. The study underscores the synthetic value of inexpensive small-molecule organic photocatalysts in the generation of structural complexity via sequential ?€-bond activation.

Identification and initial SAR of silybin: An Hsp90 inhibitor

Through Hsp90-dependent firefly luciferase refolding and Hsp90-dependent heme-regulated eIF2α kinase (HRI) activation assays, silybin was identified as a novel Hsp90 inhibitor. Subsequently, a library of silybin analogues was designed, synthesized and evaluated. Initial SAR studies identified the essential, non-essential and detrimental functionalities on silybin that contribute to Hsp90 inhibition.

PYRIDYLPHENOL COMPOUND AND USE THEREOF

The present invention provides a compound which has metastin receptor antagonist activity and is useful for preventing and treating hormone-dependent cancer, benign prostatomegaly, endometriosis, precocious puberty, uterine myoma or the like. More specifically, the present invention provides a compound, represented by the formula: or a salt thereof, a prodrug thereof, and a pharmaceutical agent containing the same; wherein Ring A represents a 5- to 8-membered homocyclic or heterocyclic group optionally having a substituent other than formula -X-R1 wherein X represents a bond or a spacer, and R1 represents optionally substituted amino or an optionally substituted nitrogen-containing heterocyclic group; Ring B represents an optionally substituted benzene ring; R2 represents an optionally substituted homocyclic or heterocyclic group; and R3 and R4 independently represent a hydrogen atom, cyano, acyl or an optionally substituted hydrocarbon group.