65158-40-9Relevant academic research and scientific papers
2-(Trifluoromethyl)indoles via Pd(0)-Catalyzed C(sp3)-H Functionalization of Trifluoroacetimidoyl Chlorides
Pedroni, Julia,Cramer, Nicolai
supporting information, p. 1932 - 1935 (2016/06/09)
Perfluoroalkylated indoles are valuable compounds in drug discovery. A Pd(0)-catalyzed C(sp3)-H functionalization enables access to 2-(trifluoromethyl)indoles from trifluoroacetimidoyl chlorides. These are stable compounds, easily obtained from
One-Pot Synthesis of Trifluoroacetimidoyl Halides
Tamura, Kenji,Mizukami, Hiromichi,Maeda, Kazuhiro,Watanabe, Hisayuki,Uneyama, Kenji
, p. 32 - 35 (2007/10/02)
Trifluoroacetimidoyl chlorides 1 were obtained in 80-90percent yields when a mixture of trifluoroacetic acid and a primary amine was heated in carbon tetrachloride in the presence of triphenylphosphine and triethylamine.The corresponding bromides 2 were o
Homologation of trifluoroacetimidoyl iodides by palladium-catalyzed carbonylation. An approach to α-amino perfluoroalkanoic acids
Watanabe,Hashizume,Uneyama
, p. 4333 - 4336 (2007/10/02)
Homologation of trifluoroacetimidoyl iodides and the related perfluoro-compounds by palladium-catalyst under CO(1atm)-atmosphere in the presence of alcohols gives α-imino perfluoroalkanoates which are transformed to α-amino perfluoroalkanoic acids.
