65171-95-1

Upstream product

• 117917-43-8 1-Benzyl-2-hydroxy-3-oxo-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 117917-40-5 2,3-Dioxo-pent-4-enoic acid tert-butyl ester 
• 540-88-5 acetic acid tert-butyl ester 
• 125879-66-5 tert-butyl 5-chloro-2-(((p-nitrophenyl)sulfonyl)oxy)-3-oxopentanoate 
• 117917-42-7 5-Chloro-2,3-dioxo-pentanoic acid tert-butyl ester 
• 88023-66-9 tert-butyl 5-chloro-3-oxopentanoate 
• 100-46-9 benzylamine 
• 117917-41-6 5-Chloro-2-[1-dimethylamino-meth-(Z)-ylidene]-3-oxo-pentanoic acid tert-butyl ester 
• 83199-82-0 t-Butyl 5-Chloro-3-oxo-2-(triphenylphosphoranylidene)-pentanoate 

Downstream Products

• 139374-18-8 (Z)-3-(Benzyl-tert-butoxyoxalyl-amino)-acrylic acid methyl ester 
• 139374-19-9 3-Benzyl-2-methoxy-6-oxo-3,6-dihydro-2H-[1,3]oxazine-2-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

2-(((p-Nitrophenyl)sulfonyl)oxy)-3-keto Esters: Versatile Intermediates for the Preparation of 1,2,3-Tricarbonyl Compounds

The excellent leaving ability of the nosylate group and the high, differentiated functional group density in 2-(((p-nitrophenyl)sulfonyl)oxy)-3-keto esters, 1, suggested that they might serve as versatile precursors for the synthesis of other 1,2,3-trifunctionalized compounds.Reaction of 2-(nosyloxy)-3-keto esters with triethylamine gives 1,2,3-tricarbonyl compounds in high yields.The tricarbonyl compound can be reacted, without isolation, with nucleophiles to give heterocyclic products in excellent yields.

THE CHEMISTRY OF VICINAL TRICARBONYLS USE OF VINYL TRICARBONYL ESTERS IN THE FORMATION OF 3-HYDROXYPYRROLE-2-CARBOXYLATES

The reaction of primary amines with the vinyl tricarbonyl reagent 1 forms the basis of a general synthesis of N-substituted 3-hydroxypyrrole-2-carboxylates.