651718-82-0Relevant articles and documents
Synthesis of acyclic nucleotide analogues possessing a difluoromethylene phosphonyl group at the side chain
Murano, Tetsuo,Yuasa, Yoko,Kobayakawa, Hirokuni,Yokomatsu, Tsutomu,Shibuya, Shiroshi
, p. 10223 - 10230 (2007/10/03)
A synthetic approach to a new type of acyclic nucleotide analogues 8 and 9 was examined. The design was based on acyclic modification of MRS 2179, a P2Y1-antagonist, and replacement of one of two phosphate groups characterized by MRS 2179 with an isosteric difluoromethylenephosphonyl group. The nucleotide analogues 8 and 9 were enantio-divergently prepared as their ester-protecting derivatives from a highly differentiated 1,5-pentanediol derivative possessing a difluoromethylenephosphonyl group at the 3-position.