651729-01-0

Basic information

• Product Name: 3-(5-chlorosulfonyl-2-methoxyphenyl)propionic acid 2-(toluene-4-sulfonyl)ethyl ester
• Synonyms: 3-(5-chlorosulfonyl-2-methoxyphenyl)propionic acid 2-(toluene-4-sulfonyl)ethyl ester
• CAS NO: 651729-01-0
• Molecular Weight: 460.957
• Mol File: 651729-01-0.mol

Chemical Properties

• CAS DataBase Reference: 3-(5-chlorosulfonyl-2-methoxyphenyl)propionic acid 2-(toluene-4-sulfonyl)ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(5-chlorosulfonyl-2-methoxyphenyl)propionic acid 2-(toluene-4-sulfonyl)ethyl ester(651729-01-0)
• EPA Substance Registry System: 3-(5-chlorosulfonyl-2-methoxyphenyl)propionic acid 2-(toluene-4-sulfonyl)ethyl ester(651729-01-0)

Safety Data

• Hazardous Substances Data: 651729-01-0(Hazardous Substances Data)

Upstream product

• 651729-00-9 3-(2-methoxyphenyl)propionic acid 2-(toluene-4-sulfonyl)ethyl ester 

Downstream Products

• 651729-03-2 3-[2-methoxy-5-{6-methoxy-2-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethanesulfinyl)-benzimidazole-1-sulfonyl}phenyl]propionic acid 2-[toluene-4-sulfonyl]ethyl ester 

Relevant articles and documents

1-arylsulfonyl-2-(Pyridylmethylsulfinyl) benzimidazoles as new proton pump inhibitor prodrugs

New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition.

PRODRUGS OF PROTON PUMP INHIBITORS

Prodrugs of proton pump inhibitors of Formulas 1 through 4, (I-IV), where the symbols are as defined in the specification, and the R group includes at least one acidic group or its pharmaceutically acceptable salt, have improved aqueous solubility and bioavailability.