651729-37-2Relevant academic research and scientific papers
Intramolecular Oxidative Coupling between Unactivated Aliphatic C-H and Aryl C-H Bonds
Liao, Yang,Zhou, Yi,Zhang, Zhen,Fan, Junzhen,Liu, Feng,Shi, Zhangjie
supporting information, p. 1251 - 1257 (2021/03/03)
Direct oxidative coupling of different inert C-H bonds is the most straightforward and environmentally benign method to construct C-C bonds. In this paper, we developed a Pd-catalyzed intramolecular oxidative coupling between unactivated aliphatic and aryl C-H bonds. This chemistry showed great potential to build up fused cyclic scaffolds from linear substrates through oxidative couplings. Privileged chromane and tetralin scaffolds were constructed from readily available linear starting materials in the absence of any organohalides and organometallic partners.
Process for preparing isomerically pure prodrugs of proton pump inhibitors
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Page/Page column 8, (2010/02/10)
Synthetic methods for preparing isomerically pure N-arylsulfonyl derivatives of proton pump inhibitors which include a substituted benzimidazole nucleus are shown by the synthetic schemes and experimental description.
PRODRUGS OF PROTON PUMP INHIBITORS
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Page 160, (2010/02/06)
Prodrugs of proton pump inhibitors of Formulas 1 through 4, (I-IV), where the symbols are as defined in the specification, and the R group includes at least one acidic group or its pharmaceutically acceptable salt, have improved aqueous solubility and bioavailability.
