651729-83-8

Upstream product

• 651729-82-7 [4-(2-mercapto-6-methoxy-benzimidazole-1-sulfonyl)-phenoxy]acetic acid methyl ester 
• 86604-75-3 2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride 

Downstream Products

• 519182-99-1 {4-[6-methoxy-2-(4-methoxy-3,5-dimethyl-2-pyridinyl)methylsulfinylbenzimidazole-1-sulfonyl]phenoxy}acetic acid methyl ester 

Relevant academic research and scientific papers

Process for preparing isomerically pure prodrugs of proton pump inhibitors

Synthetic methods for preparing isomerically pure N-arylsulfonyl derivatives of proton pump inhibitors which include a substituted benzimidazole nucleus are shown by the synthetic schemes and experimental description.

PRODRUGS OF PROTON PUMP INHIBITORS

Prodrugs of proton pump inhibitors of Formulas 1 through 4, (I-IV), where the symbols are as defined in the specification, and the R group includes at least one acidic group or its pharmaceutically acceptable salt, have improved aqueous solubility and bioavailability.