651729-87-2

Upstream product

• 651729-85-0 3-(4-chlorosulfonyl-phenyl)-propionic acid 2-(toluene-4-sulfonyl)ethyl ester 
• 96-96-8 4-methoxy-2-nitroaniline 

Downstream Products

• 651729-88-3 3-[4-(2-amino-4-methoxy-phenylsulfamoyl)-phenyl]-propionic acid 2-(toluene-4-sulfonyl)ethyl ester 

Relevant academic research and scientific papers

Process for preparing isomerically pure prodrugs of proton pump inhibitors

Synthetic methods for preparing isomerically pure N-arylsulfonyl derivatives of proton pump inhibitors which include a substituted benzimidazole nucleus are shown by the synthetic schemes and experimental description.

PRODRUGS OF PROTON PUMP INHIBITORS

Prodrugs of proton pump inhibitors of Formulas 1 through 4, (I-IV), where the symbols are as defined in the specification, and the R group includes at least one acidic group or its pharmaceutically acceptable salt, have improved aqueous solubility and bioavailability.