651733-09-4

Basic information

• Product Name: Benzenemethanamine, 2-amino-4-nitro-
• CAS NO: 651733-09-4
• Molecular Formula: C7H9N3O2
• Molecular Weight: 167.167
• Mol File: 651733-09-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzenemethanamine, 2-amino-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, 2-amino-4-nitro-(651733-09-4)
• EPA Substance Registry System: Benzenemethanamine, 2-amino-4-nitro-(651733-09-4)

Safety Data

• Hazardous Substances Data: 651733-09-4(Hazardous Substances Data)

Upstream product

• 619-17-0 4-Nitroanthranilic acid 
• 31930-18-4 2-amino-4-nitrobenzamide 
• 99-55-8 2-methyl-5-nitroaniline 
• 651733-08-3 2-acetamido-4-nitro-α-phthalimido toluene 

Relevant articles and documents

Discovery of 5-methyl-N-(2-arylquinazolin-7-yl)isoxazole-4-carboxamide analogues as highly selective FLT3 inhibitors

A series of 4-arylamido 5-methylisoxazole derivatives with quinazoline core was designed and synthesised based on conformational rigidification of a previous type II FMS inhibitor. Most of quinazoline analogues displayed activity against FLT3 and FLT3-ITD. Compound 7d, 5-methyl-N-(2-(3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl)quinazolin-7-yl)isoxazole-4-carboxamide, exhibited the most potent inhibitory activity against FLT3 (IC50= 106 nM) with excellent selectivity profiles over 36 other protein kinases including cKit and FMS kinase. Compound 7d was also active in FLT-ITD, with an IC50 value of 301 nM, and other FLT3 mutants showing potential as an AML therapeutics.

Nitroaryl phosphoramide compositions and methods for targeting and inhibiting undesirable cell growth or proliferation

The present invention relates to nitroaryl-substituted phosphoramide prodrug compounds and methods of producing the same for use in targeting and inhibiting undesirable cell growth or proliferation.