651749-29-0Relevant academic research and scientific papers
Synthesis of some n-aryl α-Amino acids using diaryliodonium salts
Mckerrow, Jason D.,Al-Rawi, Jasim M.,Brooks, Peter
experimental part, p. 1227 - 1236 (2012/09/22)
Bis[(3'-methoxycarbonyl)phenyl]iodonium bromide (4a), bis (4'-methoxyphenyl)iodonium iodide (4b) and bis (4'-acetamidophenyl)iodonium iodide (4c) were employed for the first time in the arylation of α-amino acid methyl esters. Yields of the synthesised products 5, 6 and 7 were good to high. These were then hydrolyzed to the corresponding N-aryl α-amino acids 8 and 9. The chiral integrity of the amino acids was maintained throughout the reaction sequence as confirmed by the synthesis of chiral tripeptide 10 and dipeptides 11. The structures of the new compounds were confirmed by IR, 1H and 13C NMR in addition to CHN microanalysis or high resolution mass spectrometry.
Ureido substituted benzoic acid compounds and their use for nonsense suppression and the treatment of disease
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Page/Page column 49, (2008/06/13)
The invention encompasses ureido substituted benzoic acid compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.
UREIDO SUBSTITUTED BENZOIC ACID COMPOUNDS AND THEIR USE FOR NONSENSE SUPPRESSION AND THE TREATMENT OF DISEASE
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Page 91-92, (2010/02/06)
The invention encompasses ureido substituted benzoic acid compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.
