651769-40-3

Usage

Tetrazole derivative

A five-membered heterocyclic compound The structure consists of a ring with four nitrogen atoms and a central carbon atom, making it a tetrazole.

Substitution with 3-chloro-4-fluorophenyl group

A specific type of aryl group The presence of this group on the tetrazole ring imparts unique chemical and physical properties to the compound.

Potential applications

Pharmaceutical, agrochemical, and materials science Due to its unique chemical structure and reactivity, 1H-Tetrazole, 5-(3-chloro-4-fluorophenyl)- may be used in various fields, such as drug development, pesticides, and advanced materials.

Unique chemical structure

The combination of tetrazole ring and substituent groups The presence of the 3-chloro-4-fluorophenyl group on the tetrazole ring contributes to the compound's distinct chemical properties and reactivity.

Reactivity

Influenced by the tetrazole ring and substituent groups The compound's reactivity is affected by the presence of the nitrogen atoms in the ring and the chlorine and fluorine atoms on the aryl group, which can participate in various chemical reactions.

Relevant academic research and scientific papers

Synthetic method of aromatic ring group or aromatic heterocyclic tetrazole

The synthetic method comprises the following steps: (1) reacting 1.0 eq of ArI or HArI with 1.2 eq of ethyl 2, 2-difluoroacetate in the presence of DMSO as a solvent and 4.0 eq of Cu under the protection of nitrogen at 30 DEG C and 50 DEG C, and purifying to obtain a first intermediate compound; (2) dissolving 1.0 eq of the first intermediate compound in a mixed solvent of THF and water, adding 2.0 eq of LiOH, reacting at room temperature for 2 hours, spin-drying the solvent, adding HCl until the pH value is equal to 3, and filtering to obtain a second intermediate compound; and (3) reacting 1.0 eq of the second intermediate compound with 2.0 eq of diphenyl azide phosphate in the presence of 2.5 eq of triethylamine by taking tert-butyl alcohol as a solvent to generate aromatic ring group or aromatic heterocyclic tetrazole. The invention provides a novel synthetic method of aromatic ring group or aromatic heterocyclic tetrazole, wherein a target compound can be more conveniently obtained, and reagents participating in the reaction are low in toxicity, mild in reaction condition, simple and safe in aftertreatment, good in product quality and suitable for large-scale production.

5-Aryltetrazole Compounds, compositions thereof, and uses therefor

The present invention relates to 5-Aryltetrazole compounds, compositions comprising a 5-Aryltetrazole compound, and methods for treating an inflammation disease, a reperfusion disease, hyperuricemia, gout, or tumor-lysis syndrome in an animal in need ther