651780-38-0 Usage
The chemical structure contains an indazole ring
The compound has a 5-membered nitrogen-containing ring system.
Bromo substituent at the 6 position
A bromine atom is attached to the 6th carbon of the indazole ring.
Sulfonyl group at the 3-position
A sulfonyl group (-SO2-) is attached to the 3rd carbon of the indazole ring.
4-Fluorophenyl group
A phenyl ring with a fluorine atom attached to the 4th carbon is connected to the sulfonyl group.
Trimethylsilyl ethoxy methyl group at the 1-position
A trimethylsilyl group (-Si(CH3)3) is attached to an ethoxymethyl group (-OCH2CH3) which is connected to the 1st carbon of the indazole ring.
Significant pharmacological properties
The compound is likely to have biological activity and potential as a drug.
Use in medicinal chemistry research
The compound may be used in the development of new drugs.
Enhanced biological activity
The presence of the fluorophenyl and trimethylsilyl groups may increase the potential biological activity of the compound.
Synthetic utility
The presence of the trimethylsilyl group may make the compound more useful in chemical synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 651780-38-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,5,1,7,8 and 0 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 651780-38:
(8*6)+(7*5)+(6*1)+(5*7)+(4*8)+(3*0)+(2*3)+(1*8)=170
170 % 10 = 0
So 651780-38-0 is a valid CAS Registry Number.
651780-38-0Relevant academic research and scientific papers
FUSED HETEROARYL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS IN THE TREATMENT OF I.A. RHEUMATOID ARTHRISTIS
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Page/Page column 56, (2010/11/30)
Compounds of formula (I): wherein A is a 5-membered heteroaryl ring are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38, such as rheumatoid arthritis.
