65185-07-1

Upstream product

• 16735-19-6 2-amino-1-phenylpropan-1-one hydrochloride 
• 23652-89-3 (Z)-3-Amino-1-phenyl-propenone 

Relevant academic research and scientific papers

Differential Reactivity of β-Amino Enones and 3-Dimethylaminoacrylaldehyde towards α-Amino Derivatives

Unsubstituted β-amino enones react with α-amino derivatives by a well established route with implies a fast transamination process - 1,4-addition followed by elimination - and cyclodehydration of the intermediate to 3-functionalized pyrroles.In contrast, 3-dimethylaminoacrylaldehyde undergoes 1,2-addition followed by cyclization to give the final 2-substituted pyrroles.Isolation of the intermediates supports the proposed mechanism for each reaction.