65192-28-1Relevant articles and documents
Inhibitor of heat shock factor 1, and preparation method and application of inhibitor
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Paragraph 0191; 0202-0204, (2019/12/08)
The invention provides an inhibitor of a heat shock factor 1 (HSF1) and an application of the inhibitor, particularly a compound as shown in a formula I or pharmaceutically-acceptable salt of the compound. The compound has excellent HSF1 restraining activity and tumor resisting effects. The invention further provides a medical composition containing the compound and an application of the medical composition in the respect of restraining HSF1.
Design, synthesis and biological evaluation of some novel N-arylpyrazole derivatives bearing the sulfonamide moiety as cytotoxic agents
Duan, Xiaobo,Wang, Yingxing,Feng, Weipei,Yang, Yaxing,Li, Hongyan,Li, Shenghui,Yang, Xiaobing,Zhang, Jinchao,Wang, Shuxiang,Zhou, Guoqiang,Zhou, Chuanqi
, p. 271 - 281 (2017/01/14)
A series of novel N-arylpyrazole derivatives (4a–4l) bearing the sulfonamide moiety were synthesized by the condensation reaction of 1,3-dicarbonyl compounds with 4-hydrazinylbenzenesulfonamide. The structures of the obtained compounds were established on
Synthesis and biological evaluation of some novel N-arylpyrazole derivatives as cytotoxic agents
Li, Shenghui,Xu, Shengjie,Ding, Shan,Zhang, Jinchao,Wang, Shuxiang,Li, Xiaoliu
, p. 1459 - 1468 (2014/05/06)
A series of novel N-arylpyrazole derivatives, 5a-5i, were achieved from substituted phenylacetic acid via Vilsmeier-Haack reaction, hydrolysis, condensation, and aromatic substitution reaction. Their chemical structures were confirmed by 1H NMR