652149-25-2

Upstream product

• 652149-23-0 6-azidohexyl (6-O-tert-butyldiphenylsilyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl)-(1->3)-4-O-acetyl-2,6-di-O-benzyl-β-D-galactopyranoside 
• 652149-21-8 6-azidohexyl (3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl)-(1->3)-4-O-acetyl-2,6-di-O-benzyl-β-D-galactopyranoside 
• 652149-22-9 6-azidohexyl (2-deoxy-2-phthalimido-β-D-glucopyranosyl)-(1->3)-4-O-acetyl-2,6-di-O-benzyl-β-D-galactopyranoside 
• 488140-36-9 6-azidohexyl 4-O-acetyl-2,6-di-O-benzyl-β-D-galactopyranoside 
• 652149-24-1 6-azidohexyl (6-O-tert-butyldiphenylsilyl-2-deoxy-3,4-di-O-p-methylbenzoyl-2-phthalimido-β-D-glucopyranosyl)-(1->3)-4-O-acetyl-2,6-di-O-benzyl-β-D-galactopyranoside 

Downstream Products

• 652149-26-3 6-azidohexyl (2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-(1->6)-(2-deoxy-3,4-di-O-p-methylbenzoyl-2-phthalimido-β-D-glucopyranosyl)-(1->3)-4-O-acetyl-2,6-di-O-benzyl-β-D-galactopyranoside 

Relevant academic research and scientific papers

Chemo-enzymatic synthesis of tetra-, penta-, and hexasaccharide fragments of the capsular polysaccharide of Streptococcus pneumoniae type 14

The chemo-enzymatic synthesis is described of β-D-Glcp-(1→6)- [β-D-Galp-(1→4)]-β-D-GlcpNAc-(1→3)-β-D-Galp- (1→O(CH2)6NH2 (1), β-D-Glcp- (1→6)-[β-D-Galp-(1→4)]-β-D-GlcpNAc-(1→3) -β-D-Galp-(1→4)-β-D-Glcp-(1→O(CH2) 6NH2 (2), β-D-Galp-(1→4)-β-D-GlcpNAc- (1→3)-β-D-Galp-(1→4)-β-D-Glcp-(1→O(CH2) 6NH2 (3), and β-D-Galp-(1→4)-β-D-GlcpNAc- (1→3)-β-D-Galp-(1→4)-β-D-Glcp-(1→6)-[β-D-Galp- (1→4)]-β-D-GlcpNAc-(1→O(CH2)6NH 2 (4), representing fragments of the repeating unit of the Streptococcus pneumoniae serotype 14 capsular polysaccharide. Linear intermediate oligosaccharides 5-8 were synthesized via chemical synthesis, followed by enzymatic galactosylation using bovine milk β-1,4- galactosyltransferase as a catalyst. The title oligosaccharides form suitable compounds for conjugation with carrier proteins, to be tested as potential vaccines in animal models.