65220-86-2

Basic information

• Product Name: 1-(trifluoroacetyl)piperidin-4-one
• Synonyms: 1-(trifluoroacetyl)piperidin-4-one;Albb-003887;1-(trifluoroacetyl)-4-piperidinone(SALTDATA: FREE);1-(Trifluoroacetyl)-4-piperidinone;1-(2,2,2-TRIFLUOROACETYL)PIPERIDIN-4-ONE
• CAS NO: 65220-86-2
• Molecular Formula: C₇H₈F₃NO₂
• Molecular Weight: 195.14
• Mol File: 65220-86-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 234.375°C at 760 mmHg
• Flash Point: 95.547°C
• Appearance: /
• Density: 1.378g/cm³
• Vapor Pressure: 0.053mmHg at 25°C
• Refractive Index: 1.428
• CAS DataBase Reference: 1-(trifluoroacetyl)piperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(trifluoroacetyl)piperidin-4-one(65220-86-2)
• EPA Substance Registry System: 1-(trifluoroacetyl)piperidin-4-one(65220-86-2)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• HazardClass: IRRITANT
• Hazardous Substances Data: 65220-86-2(Hazardous Substances Data)

Usage

General Description

1-(trifluoroacetyl)piperidin-4-one is a chemical compound which belongs to the class of organic compounds known as piperidones. These are piperidines carrying a keto group at the 1-position. This particular compound is characterized by having a trifluoroacetyl group (which is an acetyl group wherein all three hydrogen atoms are replaced by fluorine atoms), attached to the nitrogen atom of the piperidin-4-one structure. At present, limited information is available regarding its specific functions or uses, and it is mainly mentioned in the context of chemical research and synthesis. Its detailed properties such as chemical stability, reactivity, and health risks are typically documented in Material Safety Data Sheets (MSDS) specific to the compound.

InChI:InChI=1/C7H8F3NO2/c8-7(9,10)6(13)11-3-1-5(12)2-4-11/h1-4H2

Upstream product

• 93343-02-3 N-trifluoroacetyl-4-hydroxypiperidine 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 41979-39-9 4-piperidone hydrochloride 
• 40064-34-4 4-piperidone monohydrochloride monohydrate 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 359881-71-3 2-(4-chlorophenyl)-N-(4-methylbenzyl)-N-(1-ethylpiperidin-4-yl)acetamide hydrochloride 
• 359879-55-3 N-((3-hydroxy-4-methylphenyl)methyl)-4-amino-1-methylpiperidine 
• 359879-02-0 2-(4-Methoxyphenyl)-N-(4-methylbenzyl)-N-[1-(2-methylthiazol-4-ylmethyl) piperidin-4-yl] acetamide 
• 732977-32-1 2-(4-Methoxyphenyl)-N-(4-methylbenzyl)-N-(1-trifluoroacetylpiperidin-4-yl) acetamide 
• 359879-81-5 2-(4-Chlorophenyl)-N-(4-methylbenzyl)-N-(1-isopropylpiperidin-4-yl)-acetamide 

Relevant articles and documents

SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME

The present invention relates to processes and intermediates for preparing 3-(cyanomethyl)-3-(4-{[(1R,2S)-2-phenylcyclopropyl]amino}piperidin-1-yl)azetidine-1-sulfonamide, and salts and solid forms thereof, which selectively modulate demethylase. Particular embodiments contemplate compounds and disease indications amenable to treatment by modulation of lysine specific demethylase-1 (LSD1).

AZACYCLIC COMPOUNDS

Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In the method, an effective amount of a compound is adminstered to a patient in need of such treatment.

N-SUBSTITUTED PIPERIDINE DERIVATIVES AS SEROTONIN RECEPTOR AGENTS

Disclosed herein are isolated forms of the compounds of Formula (I), (II), (III), (IV) and (V), or a pharmaceutically acceptable salt, prodrug, hydrate, solvate, polymorph, or ester thereof. Also disclosed are methods of inhibiting an activity of a serotonin receptor, methods inhibiting an activation of a serotonin receptor, and methods of alleviating or treating various disease conditions and side effects.