Triethylsilyl-N,N,N',N'-tetramethyl-phosphordiamidit (TES-TMPD) is a chemical compound used in organic chemistry as a protecting group for amines. It is a stable, crystalline solid that is sensitive to moisture and air, requiring careful handling and storage. Its main function is to temporarily mask the amino group in a molecule, allowing for specific reactions to occur without interference from the amine functionality. After the desired reactions have taken place, the TES-TMPD protecting group can be easily removed, revealing the free amine group.
65220-87-3
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Basic information
- Product Name: Triethylsilyl-N.N.N'.N'-tetramethyl-phosphordiamidit
- Synonyms:
- CAS NO:65220-87-3
- Molecular Formula:
- Molecular Weight: 250.396
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: N/A
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: Triethylsilyl-N.N.N'.N'-tetramethyl-phosphordiamidit(CAS DataBase Reference)
- NIST Chemistry Reference: Triethylsilyl-N.N.N'.N'-tetramethyl-phosphordiamidit(65220-87-3)
- EPA Substance Registry System: Triethylsilyl-N.N.N'.N'-tetramethyl-phosphordiamidit(65220-87-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 65220-87-3(Hazardous Substances Data)
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65220-87-3 Usage
Uses
Used in Pharmaceutical Synthesis:TES-TMPD is used as a protecting agent for amino groups in the synthesis of pharmaceuticals. It allows for selective protection of the amino groups, enabling specific reactions to occur without interference. This is crucial for the development of complex molecules with precise structural requirements.
Used in Agrochemical Synthesis:
TES-TMPD is also used as a protecting agent for amino groups in the synthesis of agrochemicals. Similar to its application in pharmaceuticals, it enables selective protection and facilitates complex chemical transformations, contributing to the development of new compounds with desired properties.
Used in Organic Synthesis:
TES-TMPD is used as a protecting group in organic synthesis to selectively protect amine groups. This allows for the facilitation of complex chemical transformations, making it a valuable tool in the development of new compounds with specific functionalities.
Check Digit Verification of cas no
The CAS Registry Mumber 65220-87-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,2,2 and 0 respectively; the second part has 2 digits, 8 and 7 respectively.Calculate Digit Verification of CAS Registry Number 65220-87:
(7*6)+(6*5)+(5*2)+(4*2)+(3*0)+(2*8)+(1*7)=113
113 % 10 = 3
So 65220-87-3 is a valid CAS Registry Number.
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Triethylsilyl-N.N.N'.N'-tetramethyl-phosphordiamidit
