65222-65-3

Basic information

• Product Name: (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionic acid (R)-1,5-dimethylhex-4-enyl ester
• CAS NO: 65222-65-3
• Molecular Weight: 344.374
• Mol File: 65222-65-3.mol

Chemical Properties

• CAS DataBase Reference: (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionic acid (R)-1,5-dimethylhex-4-enyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionic acid (R)-1,5-dimethylhex-4-enyl ester(65222-65-3)
• EPA Substance Registry System: (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionic acid (R)-1,5-dimethylhex-4-enyl ester(65222-65-3)

Safety Data

• Hazardous Substances Data: 65222-65-3(Hazardous Substances Data)

Upstream product

• 39637-99-5 (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride 
• 58917-27-4 (R)-sulcatol 
• 533-67-5 2-Deoxy-D-ribose 

Relevant articles and documents

ISOMETHEPTENE ISOMER

The invention relates to a purified Isometheptene compound comprising the structure according to Formula (I), or a hydrochloride, or a pharmaceutically acceptable addition salt thereof. In particular, the disclosure relates to the synthesis, purification and characterization of an Isometheptene isomer mucate crystal 2, wherein the Isometheptene isomer 2 is stereochemically characterized as (R)-enantiomer, respectively. The Isometheptene (R)-enantiomer activity indicates a selective centrally acting selective ligand for Imidazoline subtype 1 (I1) receptor sites; and more specifically, the disclosure provides an antihypertensive composition for treatment of migraine and other neurovascular or neurogenic pain from abdominal distress. (R)-Isometheptene enantiomer or isomer 2 may be an anti-hypertensive agent with lower side effects than the racemate form. Therefore (R)-Isometheptene is believed to be effective against episodic tension-type headaches (ETTH). The (R)-Isometheptene enantiomer or isomer 2 is believed to effectively lower blood pressure, used alone or together with other headache ameliorating drugs. Methods of synthesis and treatment are described. Regarding (R)-Isometheptene crystals data of X-ray crystallography are presented.