65223-79-2 Usage
General Description
2(1H)-Pyrimidinone, 4-amino-5-ethynyl- (9CI) is a chemical compound consisting of a pyrimidinone ring with an amino group at the 4th position and an ethynyl group at the 5th position. It is commonly used in medicinal chemistry research for the development of new drugs, particularly as an antineoplastic agent. The ethynyl group provides a unique chemical functionality that can be targeted for specific interactions with biological targets, potentially leading to enhanced drug efficacy and selectivity. 2(1H)-Pyrimidinone, 4-amino-5-ethynyl- (9CI) is also of interest in the field of organic synthesis, as the ethynyl group can serve as a versatile handle for the installation of additional functional groups.
Check Digit Verification of cas no
The CAS Registry Mumber 65223-79-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,2,2 and 3 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 65223-79:
(7*6)+(6*5)+(5*2)+(4*2)+(3*3)+(2*7)+(1*9)=122
122 % 10 = 2
So 65223-79-2 is a valid CAS Registry Number.
65223-79-2Relevant academic research and scientific papers
Ethynyl side chain hydration during synthesis and workup of "clickable" oligonucleotides: Bypassing acetyl group formation by triisopropylsilyl protection
Ingale, Sachin A.,Mei, Hui,Leonard, Peter,Seela, Frank
, p. 11271 - 11282 (2013/12/04)
Clickable oligonucleotides with ethynyl residues in the 5-position of pyrimidines (ethdC and ethdU) or the 7-position of 7-deazaguanine (ethc7Gd) are hydrated during solid-phase oligonucleotide synthesis and workup conditions. The side products were identified as acetyl derivatives by MALDI-TOF mass spectra of oligonucleotides and by detection of modified nucleosides after enzymatic phosphodiester hydrolysis. Ethynyl → acetyl group conversion was also studied on ethynylated nucleosides under acidic and basic conditions. It could be shown that side chain conversion depends on the nucleobase structure. Triisopropylsilyl residues were introduced to protect ethynyl residues from hydration. Pure, acetyl group free oligonucleotides were isolated after desilylation in all cases.
