65239-33-0

Upstream product

• 540-80-7 tert.-butylnitrite 
• 3609-53-8 methyl 4-acetylbenzoate 

Downstream Products

• 65239-24-9 4,4'-(bis-hydroxyimino-succinyl)-bis-benzoic acid dimethyl ester 
• 65239-26-1 4,4'-[1,2,5]oxadiazolo[3,4-d]pyridazine-4,7-diyl-bis-benzoic acid dimethyl ester 
• 65239-25-0 4,4'-(furazan-3,4-dicarbonyl)-bis-benzoic acid dimethyl ester 

Relevant academic research and scientific papers

Method for directly synthesizing furoxan from methyl ketone

The invention discloses a method for directly synthesizing furoxan from methyl ketone, and belongs to the technical field of organic chemical synthesis. According to the method, methyl ketone is usedas a raw material, methyl ketone and a green nitration r

Diacylfuroxans Are Masked Nitrile Oxides That Inhibit GPX4 Covalently

GPX4 represents a promising yet difficult-to-drug therapeutic target for the treatment of, among others, drug-resistant cancers. Although most GPX4 inhibitors rely on a chloroacetamide moiety to modify covalently the protein's catalytic selenocysteine residue, the discovery and mechanistic elucidation of structurally diverse GPX4-inhibiting molecules have uncovered novel electrophilic warheads that bind and inhibit GPX4. Here, we report our discovery that diacylfuroxans can act as masked nitrile oxide prodrugs that inhibit GPX4 covalently with unique cellular and biochemical reactivity compared to existing classes of GPX4 inhibitors. These observations illuminate a novel molecular mechanism of action for biologically active furoxans and also expand the collection of reactive groups capable of targeting GPX4.

Solvent-free mechanochemical synthesis of diacylfuroxans

Acetophenones with a variety of substituents could be converted to diacylfuroxans in a solvent-free reaction by combining the reagents Fe(NO3)3·9H2O and P2O5 under high-speed ball milling. This reacti